Platelet Activation in Patients with Obstructive Sleep Apnea Syndrome and Effects of Nasal-Continuous Positive Airway Pressure
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概要
- 論文の詳細を見る
Objective: Our study was undertaken to determine whether increased platelet activation occurs in patients with obstructive sleep apnea syndrome (OSAS) and whether a therapy with nasal-continuous positive airway pressure (N-CPAP) alters this activation. Methods: We measured the positive rate of activated platelets using activation-dependent monoclonal antibodies (MoAb) and flow cytometry in whole blood from 94 patients with OSAS, and from 31 age-matched controls. Thrombotic vascular diseases were surveyed as a background of alternative of platelet activation. Results: The positive rate for activated platelets was significantly higher in patients with OSAS (PAC1 52.6±22.9%, CD62P 6.8±7.1%, mean±SD), as compared with healthy control subjects (PAC1 16.7±8.6%, CD62P 0.7±0.5%, p<0.001). The activation indexes were significantly reduced after 1 month with N-CPAP treatment as a whole (PAC1; from 52.6±22.9 to 44.2±22.4, p<0.05, CD62P; from 6.8±7.1 to 5.3±5.5, p<0.05). In nearly 60% of patients, platelets activation remained high despite significant improvement of sleep apnea-episodes after N-CPAP. These patients had significantly higher incidence of previous myocardial infarction and/or cerebral infarction and abnormalities of head MRI and carotid sonograpy; indicating that the platelet activation appears to be induced by existing atheroma plaque and not by sympathetic activity in OSAS. Conclusion: In conclusion, patients with OSAS have increased percentages of activated platelets as assessed by flow cytometrical analysis of activation dependent surface markers, and were divided into two groups, one group with response to N-CPAP treatment in the reduction of platelet activation and the other without. One possible reason of no response to N-CPAP treatment in the reduction of platelet activation was suggested to be thrombotic diseases.
- 東海大学の論文
著者
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MIYACHI Hayato
Department of Laboratory Medicine, Tokai University School of Medicine
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Yamamoto Masahiro
Department Of Surgery Teikyo University School Of Medicine
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ONO Yoshiaki
Department of Physics,Nagoya University
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ANDO Yasuhiko
Department of Blood Transfusion Service Center Tokai University Hospital
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Miyachi H
Tokai Univ. School Of Medicine Kanagawa
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Miyachi Hayato
Department Of Laboratory Medicine Tokai University School Of Medicine
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Miyachi Hayato
東海大学 薬理
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HAIDA Munetaka
Departments of Neurology Tokai University School of Medicine
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Shimizu Masaki
Department Of Internal Medicine School Of Medicine Tokai University
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Haida Munetaka
Department Of Internal Medicine School Of Medicine Tokai University
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Haida Munetaka
Department Of Physiology Tokai University School Of Medicine
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Shinohara Yukito
Department of Internal Medicine (METABOLISM and ENDOCRINOLOGY), Graduate School of Comprehensive Hum
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Shinohara Yukito
Department Of Cardiology Miyazaki Medical Association Hospital
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Ono Yoshiaki
Department Of Geriatric Dentistry Osaka Dental University
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SHIMIZU Mie
Department of Laboratory Medicine, Tokai University School of Medicine
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KAMIO Kazutaka
Department of Pulmonary Medicine, Tokai University School of Medicine
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Shimizu Mie
Department Of Laboratory Medicine Tokai University School Of Medicine
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Ando Y
Department Of Laboratory Medicine Tokai University School Of Medicine
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Ando Yasuhiko
Department Of Laboratory Medicine Tokai University School Of Medicine
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Kamio Kazutaka
Department Of Pulmonary Medicine Tokai University School Of Medicine
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Yamamoto Masahiro
Department Of Earth Sciences Okayama University
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Shinohara Yukito
Department Of Neurology Tokai University School Of Medicine
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Ono Yoshiaki
Department Of Pulmonary Medicine Tokai University School Of Medicine
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Yamamoto Masahiro
Tokai Univ. School Of Medicine
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Yamamoto Masahiro
Department Of Agricultural Chemistry Faculty Of Agriculture Niigata University
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Shinohara Yukito
Department of Neurology, Tokai University School of Medicine
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MIYACHI HAYATO
Department of Internal Medicine, School of Medicine, Keio University
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