Flow cytometric analysis of skin blister fluid induced by mosquito bites in a patient with chronic active Epstein-Barr virus infection
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概要
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出版者に照会中.2010年12月より全文公開予定.In chronic active Epstein-Barr virus (EBV) infection (CAEBV), ectopic EBV infection has been described in T or natural killer (NK) cells. NK cell-type infection (NK-CAEBV) is characterized by large granular lymphocytosis, high IgE levels and unusual reactions to mosquito bites, including severe local skin reactions, fever and liver dysfunction. However, the mechanisms underlying these reactions remain undetermined. Herein, we describe a patient with NK-CAEBV whose blister fluid after mosquito bites was analyzed. The patient exhibited significant increases in the percentage of CD56+ NK cells in the fluid compared with a simple mosquito allergy, in which the majority of infiltrated cells were CD203c+ cells, indicating basophils and/or mast cells. His fluid also contained CD203c+ cells, and his circulating basophils were activated by mosquito extracts in vitro. These results suggest that CD203c+ cells as well as NK cells may play pathogenic roles in the severe skin reactions to mosquito bites in NK-CAEBV. © 2009 The Japanese Society of Hematology.
- The Japanese Society of Hematology = 日本血液学会の論文
- 2009-12-15
著者
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Yoshimoto A
Department Of Pediatrics School Of Medicine Institute Of Medical Pharmaceutical And Health Sciences
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WADA Taizo
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Scienc
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YOKOYAMA Tadafumi
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Scienc
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NAKAGAWA Hiroyasu
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Scienc
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ASAI Erika
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Scienc
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TOGA Akiko
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Scienc
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SAKAKIBARA Yasuhisa
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Scienc
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SHIBATA Fumie
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Scienc
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TONE Yumi
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Scienc
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SHIMIZU Masaki
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Scienc
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TOMA Tomoko
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Scienc
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YACHIE Akihiro
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Scienc
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Tone Yumi
金沢大学 医学系研究科医薬保健学域医療類小児科学
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Tone Yumi
Department Of Pediatrics School Of Medicine Institute Of Medical Pharmaceutical And Health Sciences
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Tone Yumi
Department Of Pediatrics Graduate School Of Medical Science Kanazawa University
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Shibata Fumie
Department Of Pediatrics School Of Medicine Institute Of Medical Pharmaceutical And Health Sciences
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Shimizu Masaki
Department Of Internal Medicine School Of Medicine Tokai University
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Wada Taizo
Department Of Pediatrics School Of Medicine Institute Of Medical Pharmaceutical And Health Sciences
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Wada Taizo
Department Of Cardiology Kokura Memorial Hospital
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Toma Tomoko
Department Of Pediatrics School Of Medicine Institute Of Medical Pharmaceutical And Health Sciences
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Toma Tomoko
Department Of Pediatrics Graduate School Of Medical Science Faculty Of Medicine Kanazawa University
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Yachie Akihiro
Department Of Pediatrics School Of Medicine Institute Of Medical Pharmaceutical And Health Sciences
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Yoshimoto Akihiro
Faculty Of Biological Science Hiroshima University
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Shimizu Masaki
Department Of Pediatrics School Of Medicine Institute Of Medical Pharmaceutical And Health Sciences
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Sakai Yoshio
Department Of Pediatrics School Of Medicine Institute Of Medical Pharmaceutical And Health Sciences
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Yachie Akihiro
Department Of Laboratory Science Kanazawa University Faculty Of Medicine
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Ishida Yasushi
Department Of Pediatrics Graduate School Of Medical Science Kanazawa University
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Toga Akiko
Department Of Pediatrics School Of Medicine Institute Of Medical Pharmaceutical And Health Sciences
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Asai Erika
Department Of Pediatrics School Of Medicine Institute Of Medical Pharmaceutical And Health Sciences
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Nakagawa Hiroyasu
Department Of Pediatrics School Of Medicine Institute Of Medical Pharmaceutical And Health Sciences
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Yokoyama Tadafumi
Department Of Pediatrics School Of Medicine Institute Of Medical Pharmaceutical And Health Sciences
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Wada T
Department Of Pediatrics School Of Medicine Institute Of Medical Pharmaceutical And Health Sciences
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Toma Tomoko
Department Of Angiogenesis And Vascular Development School Of Medicine Kanazawa University
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Wada Taizo
Department Of Angiogenesis And Vascular Development School Of Medicine Kanazawa University
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Yachie Akihiro
Department Of Pediatrics School Of Medicine Institute Of Medical Pharmaceutical And Health Sciences
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Shibata Fumie
Department Of Pediatrics Graduate School Of Medical Sciences Kanazawa University
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Shimizu Masaki
Department Of Angiogenesis And Vascular Development School Of Medicine Kanazawa University
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Yachie Akihiro
Department Of Angiogenesis And Vascular Development School Of Medicine Kanazawa University
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Yachie Akihiro
Department Of Pediatrics School Of Medicine Institute Of Medical Pharmaceutical And Health Sciences
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Wada Taizo
Department Of Pediatrics School Of Medicine Institute Of Medical Pharmaceutical And Health Sciences
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Nakagawa Hiroyasu
Department Of Pediatrics Fukuiken Saiseikai Hospital
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Wada Taizo
Department Of Pediatrics School Of Medicine Institute Of Medical Pharmaceutical And Health Sciences
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Taga Akiko
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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