Alloimmunization Following Platelet Transfusions in Patients with Acute Nonlymphocytic Leukemia
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概要
- 論文の詳細を見る
Lymphocytotoxic (LCT) antibodies were measured in 20 adult patients with acute nonlymphocytic leukemia (ANLL) who received remission induction chemotherapy and multiple platelet transfusions. Nine (45%) became LCT positive and refractory to the platelet transfusions. This frequency of alloimmunization in ANLL patients was significantly lower than that in aplastic anemia patients (p<0.05). In one male with acute promyelocytic leukemia (APL), the LCT antibody disappeared during intensive chemotherapy and recovery of transfused platelets improved remarkably. The incidence of alloimmunization in the patients with APL appeared to be especially low. Six out of 9 LCT positive patients with ANLL became alloimmunized with less than 10 units of platelet transfusions. Three out of 11 LCT negative patients never became alloimmunized with more than 100 units. These facts indicated that there was no relationship between the number of platelet transfusions given and the development of alloimmunization. In addition, the remission rate also did not correlate with the development of alloimmunization.
- 東海大学の論文
著者
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SHIMIZU Masaki
Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Scienc
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ARIMORI Shigeru
Department of Internal Medicine, School of Medicine, Tokai University
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Arimori Shigeru
Department Of Internal Medicine Tokai University School Of Medicine
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Arimori Shigeru
東海大学 内科
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Arimori Shigeru
The Fourth Department Of Internal Medicine Tokai University
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NAGAO Tadami
Department of Internal Medicine, Tokai University School of Medicine
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NOZAKI Hiroyuki
Department of Internal Medicine, School of Medicine, Tokai University
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KOMATSUDA Mitsumoto
Department of Internal Medicine, School of Medicine, Tokai University
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WATANABE Katsuto
Department of Internal Medicine, School of Medicine, Tokai University
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長尾 忠美
東海大学医学部第四内科
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Nagao Tadami
Department Of Internal Medicine Tokai University School Of Medicine
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長尾 忠美
東海大 第4内科
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Nagao Tadami
Department Of Internal Medicine School Of Medicine Tokai University
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Watanabe Katsuto
Department Of Clinical Pathology School Of Medicine Tokai University
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Komatsuda Mitsumoto
Department Of Internal Medicine School Of Medicine Tokai University
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Nozaki H
Department Of Internal Medicine School Of Medicine Tokai University
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Nozaki Hiroyuki
東海大学 内科
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Nozaki Hiroyuki
Department Of Internal Medicine School Of Medicine Tokai University
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Shimizu Masaki
Department Of Internal Medicine School Of Medicine Tokai University
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Nagao Tadami
Internal Medicine School Of Medicine Tokai University
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Arimori Shigeru
Department Of Intenal Medicine School Of Medicine Tokai University
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Shimizu Masaki
Department Of Angiogenesis And Vascular Development School Of Medicine Kanazawa University
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Arimori Shigeru
Tokai Univ. Isehara
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Watanabe Katsuco
Department Of Clinical Pathology School Of Medicine Tokai University
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