Bone Marrow Fibroblasts-Conditioned Medium Regulates the Proliferation of Leukemic Cells
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概要
- 論文の詳細を見る
The effect of normal human bone marrow fibroblasts-conditioned medium (BMF-CM) was studied on the proliferation of K562 cells, and on leukemic cells from patients with acute myelocytic leukemia at the time of diagnosis and chronic myelogenous leukemia (CML) at chronic phase. BMF-CM was obtained from normal human bone marrow fibroblasts by using long-term liquid cultures. BMF-CM suppressed the proliferation of K562 cells and leukemic cells from patients with undifferentiated type of leukemia (Ml in FAB classification). However it stimulated the proliferation of leukemic cells from patients with differentiated type of leukemia (M2 in FAB classification), and it slightly stimulated that from patients with CML. These results suggest that normal human BMF regulate the proliferation of leukemic cells in their various stages of differentiation in the bone marrow by releasting a humoral factor.
- 東海大学の論文
著者
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Arimori Shigeru
Department Of Internal Medicine Tokai University School Of Medicine
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Arimori Shigeru
東海大学 内科
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Arimori Shigeru
The Fourth Department Of Internal Medicine Tokai University
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NAGAO Tadami
The Fourth Department of Internal Medicine, School of Medicine, Tokai University
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KUBOTA Toshihiro
The Fourth Department of Internal Medicine, School of Medicine, Tokai University
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長尾 忠美
東海大学医学部第四内科
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Nagao Tadami
Department Of Internal Medicine Tokai University School Of Medicine
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長尾 忠美
東海大 第4内科
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Nagao Tadami
The Fourth Department Of Internal Medicine School Of Medicine Tokai University
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Kubota Toshihiro
The Fourth Department Of Internal Medicine Tokai University : Fourth Department Of Internal Medicine
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Nagao Tadami
Internal Medicine School Of Medicine Tokai University
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KUBOTA Toshihiko
The Fourth Department of Internal Medicine, Tokai University
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Kubota Toshihiko
The Fourth Department Of Internal Medicine Tokai University : Fourth Department Of Internal Medicine
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Arimori Shigeru
The Fourth Department Of Internal Medicine School Of Medicine Tokai University
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Arimori Shigeru
Tokai Univ. Isehara
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