Cellular Immunity to Secretory IgA (As a Common Duct Antigen of Exocrine Glands) in Sjogren's Syndrome

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概要

• 論文の詳細を見る

• Autoimmunity to salivary duct cells has been suggested in Sjogren's syndrome (SjS). We were interested in the secretory component (SC) of secretory IgA (s-IgA) as a common duct cell antigen of systemic exocrine glands because of the possible analogy between SC in SjS and thyroglobulin in Hashimoto's thyroiditis. Therefore, we isolated s-IgA as a source of SC from human milk and investigated lymphocyte responses to s-IgA in patients with SjS. Higher mitogenic indices against s-IgA were demonstrated in SjS than in rheumatoid arthritis, other autoimmune diseases and normal persons. In addition, mitogenic indices in patients with SjS alone were significantly higher than those in SjS patients with associated diseases. These results suggest both the role of SC as a common antigen of exocrine glands in the pathology of SjS, and the presence of an etiologically different subgroup in patients with SjS.

• 東海大学の論文

著者

• Takaya Masatoshi

  Department Of Internal Medicine 4 Tokai University School Of Medicine

• Arimori Shigeru

  Department Of Internal Medicine Tokai University School Of Medicine

• Arimori Shigeru

  東海大学 内科

• Arimori Shigeru

  The Fourth Department Of Internal Medicine Tokai University

• ICHIKAWA Yukinobu

  The Fourth Department of Internal Medicine, School of Medicine, Tokai University

• TAKAYA Masatoshi

  The Fourth Department of Internal Medicine, School of Medicine, Tokai University

• Takaya M

  Department Of Internal Medicine 4 Tokai University School Of Medicine

• Tokunaga Masahito

  東海大学 内科

• Ichikawa Y

  Department Of Internal Medicine 4 Tokai University School Of Medicine

• Ichikawa Yukinobu

  東海大学 内科

• Tokunaga M

  Department Of Internal Medicine Tokai University School Of Medicine

• Takaya Masatoshi

  Department Of Internal Medicine Tokai University School Of Medicine

• Takaya M

  Department Of Internal Medicine Tokai University School Of Medicine

• Takaya Masatoshi

  The Fourth Department Of Internal Medicine School Of Medicine Tokai University

• Arimori Shigeru

  The Fourth Department Of Internal Medicine School Of Medicine Tokai University

• Takaya Masatoshi

  Tokai Univ. Isehara Jpn

• Arimori Shigeru

  Tokai Univ. Isehara

• Takaya Masatoshi

  Department Of Internal Medicine School Of Medicine

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