Circadian Variations and Prednisolone-Induced Alterations of Circulating Lymphocyte Subsets in Man.
スポンサーリンク
概要
- 論文の詳細を見る
We determined the circadian variations and prednisolone (PSL)-induced alterations of circulating lymphocyte subsets in 10 healthy adults by two-color flow cytometry using monoclonal antibodies to various lymphocyte subsets in order to collect fundamental data for monitoring of the subsets in clinical practice. This study first examined the changes of CD5+ B cells, γδ+ or γδ- T cells, activated (HLA-DR+) CD4+ or CD8+ cells, CD11b+ or CD11b-CD8+ cells, and natural killer (NK) cell subsets (CD16+CD57-, CD16+CD57+, CD16-CD57+), in addition to other subsets described before. Compared with the base line values obtained at 9:00 (AM) on day 1, lymphocytes, total B cells, CD5+ B cells, total T cells, γδ- T cells, CD4+ cells, activated CD4+ cells, CD45RA-CD4+ cells, and activated CD8+ cells were significantly increased at 20:00 (PM). However, the numbers of CD45RA+CD4+ cells, CD11b+ or CD11b-CD8+ cells and three NK cell subsets did not show significant circadian variations. After oral PSL (30 mg), which was given at 7:00 (AM) on day 2, lymphocytes and almost all lymphocyte subsets, except for CD16+CD57- cells, were significantly decreased; these changes recovered between 13 and 26 hours after PSL administration. The circadian variations and PSL-induced alterations of lymphocyte subsets were relatively comparable, but PSL administration cause a decrease in a wider range of lymphocyte subsets including relatively corticosteroid-resistant subsets such as CD45RA+CD4+ cells, CD8+ cell and NK cell subsets. Thus, these alterations of lymphocyte subsets should be taken into account in the evaluation of patients with immunologic abnormalities, especially those receiving PSL treatment.(Internal Medicine 33: 733-738, 1994)
- 社団法人 日本内科学会の論文
著者
-
ICHIKAWA Yukinobu
The Fourth Department of Internal Medicine, School of Medicine, Tokai University
-
Fukuda Ryuki
The Fourth Department Of Internal Medicine School Of Medicine Tokai University
-
Takaya Masatoshi
The Fourth Department Of Internal Medicine School Of Medicine Tokai University
-
ICHIKAWA Yukinobu
the Fourth Department of Internal Medicine, Tokai University School of Medicine
-
OGAWA Yoshiaki
The Fourth Department of Internal Medicine, Tokai University School of Medicine
-
MASUMOTO Akira
The Fourth Department of Internal Medicine, Tokai University School of Medicine
関連論文
- Experimental Induction of Sialadenitis in Rats by Heterologous Anti-Salivary Gland Antibodies
- Modulation of Peripheral Blood Lymphocyte Subsets during Methylprednisolone Pulse Therapy
- Pulmonary non-caseating granuloma in Waldenstrom macroglobulinemia
- Relationship between gastric mucosal IL-8 levels and histological gastritis in patients with Helicobacter pylori infection
- Comparison of a monoclonal with a polyclonal antibody-based enzyme immunoassay stool test in diagnosing Helicobacter pylori infection after eradication therapy
- Clinical Evaluation of 117 Patients with Sjogren's Syndrome
- Circulating Immune Complexes in Sjogren's Syndrome
- Lymphocytotoxic Antibody in Sjogren's Syndrome
- Cellular Immunity to Secretory IgA (As a Common Duct Antigen of Exocrine Glands) in Sjogren's Syndrome
- Correlation between Postsialographical Changes of Salivary Isoamylase Levels in Serum and Histopathological Findings in Sublingual Glands in Patients with Sjogren's Syndrome
- Clinical Studies on Patients with Systemic Lupus Erythematosus Associated with Sjogren's Syndrome
- Disseminated mucormycosis infection after the first course of dose-modified R-EPOCH for advanced-stage lymphoma
- Acquisition of CD13 and CD33 Expression at Relapse on Acute Myeloid Leukemia Cells with an Unusual Phenotype: MPO+CD13-CD33-.
- Circadian Variations and Prednisolone-Induced Alterations of Circulating Lymphocyte Subsets in Man.