Antibodies Against Myofibrillar Proteins in Myasthenia Gravis Patients
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概要
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Antibodies against various myofibrillar proteins were measured by enzyme-linked immunosorbent assay (ELISA) in sera of thirty-one myasthenic patients. The antibody activity expressed as optical absorbance values was higher in 15 (48%) patients for myosin, 10 (32%) patients for tropomyosin, 9 (29%) patients for troponin, 7 (23%) patients for α-actinin, and 1 (3%) patient for actin as compared with 95% tolerance limits of eleven normal individuals. Twenty-five (81%) of the patients had one of these antibodies or more. Anti-myosin antibody titer was higher in male patients (0.447±0.196; mean±SD, p<0.05) than in female patients (0.316±0.107), and positively correlated with the age of onset of myasthenia gravis (r=0.41, p<0.05). Anti-tropomyosin antibody titers had an inverse correlation with the age of onset (r=- 0.46, p<0.01). No significant correlation was found between the antibody activities and other clinical conditions, including the severity and duration of disease, and treatments (systemic treatment with corticosteroids or previous thymectomy). Positive correlations were observed between anti-myosin antibody and antitroponin antibody titers (r=0.44, p<0.02), and between anti-actin antibody and anti-α-actin in antibody titers (r=0.39, p<0.05), but no significant correlation between other pairs of antibodies against myofibrillar proteins was found. Anti-muscle striation antibodies were also determined by an indirect immunofluorescence method and their titers had a positive correlation with anti-myosin antibody titers (r=0.57, p<0.001), and both antibodies were positive in 3 (75%) out of 4 patients with thymoma which was previously removed. Anti-acetylcholine receptor antibody titers determined by a radioimmunoassay correlated positively with anti-tropomyosin antibody titer (r=0.48, p<0.01), but not with the other antibodies. The above results showed that myasthenia gravis patients have antibodies against myofibrillar proteins, particularly myosin, regardless of their thymic abnormalities.
- 東海大学の論文
著者
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Takaya Masatoshi
Department Of Internal Medicine 4 Tokai University School Of Medicine
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Kawahara Shin
National Sanatorium Okayama-minami Hospital
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Takaya Masatoshi
Departments Of Internal Medicine Tokai University School Of Medicine
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NAMBA Tatsuji
Department of Medicine, Maimonides Medical Center, and State University of New York, Health Science
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GROB David
Department of Medicine, Maimonides Medical Center, and State University of New York, Health Science
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Namba Tatsuji
Department Of Medicine Maimonides Medical Center And State University Of New York Health Science Cen
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Grob David
Department Of Medicine Maimonides Medical Center And State University Of New York Health Science Cen
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