Erythrocyte Superoxide Dismutase in Various Hematological Diseases
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概要
- 論文の詳細を見る
We measured superoxide scavenging activity (SSA) of erythrocytes with the recently developed chemiluminescence method by Nakano et al in Down syndrome and various hematological diseases. Hematological disorders were aplastic anemia, myelodysplastic snydrome, multiple myeloma, malignant lymphoma and chronic myelogenous leukemia. The SSA of erythrocytes was 1.7 times higher in Down syndrome, which was consistent with values reported in the previous publications. The erythrocyte SSA in patients of multiple myeloma trerated with interferon-alpha was higher than that in healthy volunteers. The erythrocyte SSA in myelodysplastic syndrome, malignant lymphoma and chronic myelogenous leukemia did not differ from that in healthy volunteers. The mean value of erythrocyte SSA in aplastic anemia also remained within normal range. However, when an individual's hemoglobin concentration was compared with his her own erythrocyte SSA, there was a clear correlation between them. Namely erythrocyte SSA increased when anemia was severe. There was no correlation between erythrocyte SOD activity and ageing.
- 東海大学の論文
- 1990-03-08
著者
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Nakazawa Hiroe
Department Of Cardiovascular Research Research Institute Of Environmental Medicine Nagoya University
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ARIMORI Shigeru
Department of Internal Medicine, School of Medicine, Tokai University
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Omata Fumio
東海大学 内科
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Omata Fumio
Department Of Intenal Medicine School Of Medicine Tokai University
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NAKANO MINORU
Department of Anesthesia and Intensive Care Medicine, Maebashi Red Cross Hospital
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Arimori Shigeru
Department Of Intenal Medicine School Of Medicine Tokai University
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Nakazawa Hiroe
Department Of Intenal Medicine School Of Medicine Tokai University
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Nakano Minoru
Department Of Intenal Medicine School Of Medicine Tokai University
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Nakano Minoru
Department Of Anesthesia And Intensive Care Medicine Maebashi Red Cross Hospital
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