Combined Effects of Nifekalant and Lidocaine on the Spiral-Type Re-Entry in a Perfused 2-Dimensional Layer of Rabbit Ventricular Myocardium
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概要
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Background Spiral re-entry plays the principal role in the genesis of ventricular tachycardia and ventricular fibrillation (VT/VF). The specific I_<Kr> blocker, nifekakant (NIF) has, often in combination with lidocaine (LID), recently been used in Japan to prevent recurrent VT/VF, but the combined effects of these drugs on spiral reentry had never been investigated. Methods and Results A ventricular epicardial sheet was obtained from 13 Langendorff-perfused rabbit hearts by means of a cryoprocedure, and epicardial excitations were analyzed with a high-resolution optical mapping system. Nifekakant (0.5μmol/L) caused significant prolongation of action potential duration (APD) and LID (3μmol/L) attenuated the APD prolongation without affecting the conduction velocity. VT were induced in 6 hearts by cross-field stimulation, and single-or double-loop spirals circulating around variable functional block lines were visualized during the VT. Nifekakant reduced VT cycle length and caused early termination in association with destabilization of the spiral dynamics (prolongation of functional block line, frequent local conduction block, and extensive meandering). These modifications of spiral-type re-entrant VT by NIF were prevented by addition of LID. Conclusions The effects of NIF on the spiral excitations are reversed by LID. This interaction should be taken into account when these drugs are used in combination to treat VT/VF.
- 社団法人日本循環器学会の論文
- 2005-04-20
著者
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Murato Y
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Murata Yoshiharu
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Lee Jong-kook
Division Of Cardiovascular Research Research Institute Of Environmental Medicine Nagoya University
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Lee Jong-kook
山口大学 医学系研究科器官病態内科学循環器内科
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Nakagawa Harumichi
Research Institute of Environmental Medicine, Nagoya University
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Honjo Haruo
Research Institute of Environmental Medicine, Nagoya University
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Kamiya Kaichiro
Research Institute of Environmental Medicine, Nagoya University
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Kodama Itsuo
Research Institute of Environmental Medicine, Nagoya University
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Yamamoto Mitsuru
名古屋大学環境医学研究所 循環器学
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Yamamoto M
Department Of Cardiology Mitsubishi-nagoya Hospital
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Amino Mari
Department of Cardiology, Tokai University School of Medicine
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Aikawa Minoru
Division Of Cardiology Tokai University School Of Medicine
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Amino Mari
Department Of Cardiology Tokai University School Of Medicine
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Yamazaki Masatoshi
Research Institute of Environmental Medicine, Nagoya University
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Nakazawa Hiroe
Department Of Cardiovascular Research Research Institute Of Environmental Medicine Nagoya University
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Nakagawa Harumichi
名古屋大学環境医学研究所 循環器学
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Nakagawa Harumichi
Department Of Cardiovascular Research Research Institute Of Environmental Medicine Nagoya University
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Nakagawa Harumichi
名古屋大学環境医学研究所
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Nakagawa Harumichi
Research Institute Of Environmental Medicine Nagoya University
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Yamazaki Masatoshi
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Yamazaki Masatoshi
名古屋大学環境医学研究所 循環器学
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Kamiya K
Division Of Cardiovascular Research Reseearch Institute Of Environmental Medicine Nagoya University
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Kamiya Kaichiro
名古屋大学環境医学研究所 循環器学
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Lee Jong-kook
鳥取大学 病態情報内科学
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Yoshioka Koichiro
Department of Cardiology, Tokai University School of Medicine
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TANABE Teruhisa
Division of Cardiology, Tokai University School of Medicine
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Yasui Kenji
Department Of Bioinformation Analysis Research Institute Of Environmental Medicine Nagoya University
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Tanabe Teruhisa
Department of cardiology, Tokai University
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Yasui Kenji
Research Institute Environmental Medicine Nagoya University
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Okuno Yusuke
Research Institute of Environmental Medicine, Nagoya University
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Lee Jong
Research Institute of Environmental Medicine, Nagoya University
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Horiba Mitsuru
Research Institute of Environmental Medicine, Nagoya University
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Murata Yoshiharu
Department Of Civil Engineering College Of Engineering Nihon University
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Murata Y
Department Of Teratology And Genetics Research Institute Of Environmental Medicine Nagoya University
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Lee Jong-kook
Department Of Circulation Research Institute Of Environmental Medicine Nagoya University
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Honjo Haruo
Research Institute Of Environmental Medicine Nagoya University
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Kodama Itsuo
Research Institute For Environmental Medicine Nagoya University
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Kamiya Kaichiro
Research Institute Of Environmental Medicine Nagoya Univerisyty
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Okuno Yusuke
Department Of Cardiovascular Research Research Institute Of Environmental Medicine Nagoya University
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Kanou Y
Division Of Molecular And Cellular Adaptation Research Institute Of Environmental Medicine Nagoya Un
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Kanou Yasuhiko
Department Of Genetics Research Institute Of Environmental Medicine Nagoya University
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Yasui Kenji
名古屋大学環境医学研究所
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Lee Jong-kook
Department Of Cardiovascular Research R.i.e.m. Nagoya University
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Lee Jong-kook
Research Institute Of Environmental Medicine Nagoya University
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Yamazaki Masatoshi
Division Of Cardiology Shizuoka Saiseikai General Hospital
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Hone Minoru
Department Of Cardiovascular And Respiratory Medicine Siga University Of Medical Science
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Yamazaki Masatoshi
Research Institute Of Environmental Medicine Nagoya University
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Lee Jong
Research Institute Of Chemical Technology
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Yasui Kenji
山口大学 医学系研究科器官病態内科学循環器内科
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Nakazawa Hiroe
Departments Of Physiology And Cell Transplantation Tokai University School Of Medicine
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Murata Y
Nagoya Univ. Nagoya‐shi
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Yoshioka Kouichirou
Department Of Cardiology Tokai University School Of Medicine
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Yoshioka Koichiro
Department Of Cardiology Tokai University School Of Medicine
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Tanabe Teruhisa
Department Of Cardiology School Of Medicine Tokai University
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Nakazawa Hiroe
Cardiopulmonary Division Department Of Medicine School Of Medicine Keio University
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Tanabe Teruhisa
Department Of Medicine Tokai University Hospital
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Yamazaki Masatoshi
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Tanabe Teruhisa
Department Of Internal Medicine
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Yoshioka Koichiro
Department Of Cardiology Tokai University Hospital
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Nakazawa Hiroe
Cardiopulmonary Division Dept. Of Med. School Of Med. Keio Univ.
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Yamamoto Masahiro
Yokohama City Cerebrovascular Center Yokohama Japan
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本荘 晴朗
Department Of Cardiovascular Research Research Institute Of Environmental Medicine Nagoya University
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Yoshioka Koichiro
Department Of Cardiovascular Medicine Tokai University School Of Medicine
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Okuno Yusuke
Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya University
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Honjo Haruo
Research Institute for Environmental Medicine, Nagoya University
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