Similarity between the Effects of Carbon-ion Irradiation and X-irradiation on the Development of Rat Brain

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概要

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• The effects of carbon-ion irradiation and X-irradiation on the development of rat brain were compared. Twenty pregnant rats were injected with bromodeoxyuridine (BrdU) at 9 pm on day 18 of pregnancy and divided into five groups. Three hours after injection (day 19.0) one group was exposed to 290 MeV/u carbon-ion radiation by a single dose of 1.5 Gy. Other groups were exposed to X-radiation by 1.5, 2.0 or 2.5 Gy, or sham-treated, respectively. Fetuses were removed from one dam in each group 8 h after exposure and examined histologically. Extensive cell death was observed in the brain mantle from the irradiated groups. The cell death after 1.5 Gy carbon-ion irradiation was remarkably more extensive than that after 1.5 Gy X-irradiation, but comparable to that after 2.0 Gy or 2.5 Gy X-irradiation. The remaining rats were allowed to give birth and the offspring were sacrificed at 6 weeks of age. All of the irradiated offspring manifested microcephaly. The size of the brain mantle exposed to 1.5 Gy carbon-ion radiation was significantly smaller than that exposed to 1.5 Gy X-radiation and larger than that exposed to 2.5 Gy X-radiation. A histological examination of the cerebral cortex revealed that cortical layers II-IV were malformed. The defect by 1.5 Gy carbon-ion irradiation was more severe than that by the same dose of X-irradiation. Although the BrdU-incorporated neurons were greatly reduced in number in all irradiated groups, these cells reached the superficial area of the cortex. These findings indicated that the effects of both carbon-ion irradiation and X-irradiation on the development of rat brain are similar in character, and the effect of 1.5 Gy carbon-ion irradiation compares to that of 2.0-2.5 Gy X-irradiation.

• 日本放射線影響学会の論文

著者

• Murato Y

  Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch

• Murata Yoshiharu

  Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch

• 井上 稔

  名古屋大学環境医学研究所

• 井上 稔

  新日本科学

• Yamazaki Masatoshi

  Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch

• Kubota Y

  Research Center For Radiation Safety National Institute Of Radiological Sciences

• INOUYE MINORU

  Shin Nippon Biomedical Laborarories

• TAKAHASHI SENTARO

  The 4th Research Group, National Institute of Radiological Sciences

• KUBOTA YOSHIHISA

  The 4th Research Group, National Institute of Radiological Sciences

• HAYASAKA Shizu

  Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya Universi

• MURATA Yoshiharu

  Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya Universi

• 早坂 静

  名古屋大・環境医学研究所

• Murata Yoshiharu

  Department Of Civil Engineering College Of Engineering Nihon University

• Murata Y

  Department Of Teratology And Genetics Research Institute Of Environmental Medicine Nagoya University

• INOUYE MINORU

  Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya Universi

• Hayasaka Shizu

  Department Of Genetics Research Institute Of Environmental Medicine Nagoya University

• Hayasaka Shizu

  Research Institute Of Environmental Medicine Nagoya University

• 井上 稔

  大阪府立大学 農生命科研究

• Kubota Yoshihisa

  Div. Environmental And Toxicological Res. Group Research Center For Radiation Safety National Instit

• Kubota Yoshihisa

  Division Of Comparative Radiotoxicology National Institute Of Radiological Sciences

• INOUYE MINORU

  National Institute for Minamata Disease

• Hayasaka Shizu

  名古屋大学環境医学研究所

• Hayasaka Shizu

  Res. Inst. Environ. Med. Nagoya Univ.

• Yamazaki Masatoshi

  Division Of Cardiology Shizuoka Saiseikai General Hospital

• Takahashi S

  Department Of Pediatrics And Child Health Nihon University School Of Medicine

• Inouye M

  Shin Nippon Biomedical Laborarories

• Inouye M

  Shin Nippon Biomedical Lab. Ltd. Kagoshima Jpn

• Kubota Y

  徳島大学医学部

• Kubota Y

  National Inst. Radiological Sci. Chiba Jpn

• Inouye M

  Nagoya Univ. Nagoya Jpn

• Inouye M

  Research Institute For Environmental Medicine University Of Nagoya

• Inouye Minoru

  Research Institute Of Environmental Medicine Nagoya University

• Inouye Minoru

  Pathology Section National Institute For Minamata Disease

• 井上 稔

  Research Institute Of Environmental Medicine Nagoya University

• Inouye Minoru

  Res. Inst. Environ. Med. Nagoya Univ.

• Inouye Minoru

  Department Of Nutrition Shokei University

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