Cloning of Putative Uncoupling Protein 1 cDNA in a Cold-intolerant Mammal, the House Musk Shrew (Suncus murinus)
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概要
- 論文の詳細を見る
The house musk shrew (Suncus murinus), or suncus, is a unique experimental animal. We recently showed that this mammal is cold intolerant and hypothesized that its sensitivity to cold is caused by low thermogenic activity in brown adipose tissue (BAT). Thermogenesis in BAT is performed by a unique mitochondrial protein, uncoupling protein 1 (UCP1). Interestingly, only eutherians possess UCP1, and some traits in the suncus resemble those in the Ucp1-ablated mouse, including cold intolerance, histology of BAT, and obesity resistance. In a previous study, we hypothesized that UCP1 may not be present in BAT of the suncus or may be dysfunctional. Therefore, we performed cDNA cloning of suncus Ucp1 and compared it to homologs from other species. The deduced amino acid sequence showed high similarity to other mammalian UCP1. Northern blot analysis revealed mRNA in BAT, as in other mammals. However, a difference in an amino acid residue was observed in an important residue for thermogenesis. Genomic sequence analysis showed that this difference existed in our two genetically distant laboratory colonies. These results suggest that cold intolerance in the suncus is derived from low thermogenic activity of UCP1 and may exist in wild house musk shrews.
- 社団法人 日本動物学会の論文
- 2006-11-25
著者
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ODA Sen-ichi
Laboratory of Animal Management and Resources, Graduate School of Bioagricultural Sciences, Nagoya U
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Murato Y
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Murata Yoshiharu
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Yamamoto Mitsuru
名古屋大学環境医学研究所 循環器学
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Yamamoto M
Department Of Cardiology Mitsubishi-nagoya Hospital
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Yamazaki Masatoshi
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Yamazaki Masatoshi
名古屋大学環境医学研究所 循環器学
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Oda Satoko
東邦大学 医学部解剖学
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Oda Satoko
Department Of Anatomy Toho University School Of Medicine
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Suzuki Daisuke
東海大学 医学部内科学系腎内分泌代謝内科
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Suzuki Daisuke
Central Research Laboratory Hitachi Ltd
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Suzuki D
Division Of Nephrology And Metabolism Department Of Internal Medicine Tokai University School Of Med
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MURATA Yoshiharu
Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya Universi
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Murata Yoshiharu
Department Of Civil Engineering College Of Engineering Nihon University
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Murata Y
Department Of Teratology And Genetics Research Institute Of Environmental Medicine Nagoya University
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Suzuki D
Hitachi Ltd. Tokyo Jpn
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Suzuki D
Laboratory Of Animal Management & Resources Graduate School Of Bio-agricultural Sciences Nagoya
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Murata Yoshiharu
Departments Of Genetics Research Institute Of Environmental Medicine Nagoya University
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SUZUKI Daisuke
Laboratory of Animal Management & Resources, Graduate School of Bio-Agricultural Sciences, Nagoya Un
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Murata Yoshiharu
名古屋大学環境医学研究所 発生･遺伝学
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Yoshiga Masahiko
The Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University Graduate School
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Oda Sen-ichi
Graduate School Of Agricultural Sciences Nagoya University
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Oda Sen-ichi
Laboratory Of Animal Management & Resources Graduate School Of Bio-agricultural Sciences Nagoya
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Oda S
Nagoya Univ. Nagoya Jpn
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Oda Sen-ichi
The School Of Agricultural Sciences Nagoya University
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Oda Sen-ichi
Laboratory Of Animal Management And Resources Graduate School Of Bio-agricultural Sciences Nagoya Un
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Oda Sen-ichi
Laboratory Of Animal Management & Resources Graduate School Of Bioagricultural Sciences Nagoya U
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Oda Sen-ichi
Lab. Animal Management & Resources Nagoya Univ.
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Oda Sen-ichi
Nagoya Univ.
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Oda Sen-ichi
Laboratory Of Zoology Faculty Of Agriculture Graduate School Kyushu University
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Murata Yoshiharu
Department Of Endocrinology And Metabolism Research Institute Of Environmental Medicine
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Yamazaki Masatoshi
Division Of Cardiology Shizuoka Saiseikai General Hospital
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Yamazaki Masatoshi
Research Institute Of Environmental Medicine Nagoya University
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Oda Senichi
Laboratory Of Animal Management And Resources Division Of Biosphere Resource Sciences Nagoya Univers
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Oda Sen-ichi
Graduate School Of Bio-agricultural Science Nagoya University
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Suzuki D
Central Research Laboratory Hitachi Ltd
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Murata Y
Nagoya Univ. Nagoya‐shi
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Ohta Sho
米国
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Oda Sen-ichi
School Of Agricultural Sciences Nagoya University
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Yamazaki Masatoshi
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Suzuki Daisuke
Division Of Nephrology And Metabolism Department Of Internal Medicine School Of Medicine Tokai Unive
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Yamamoto Masahiro
Yokohama City Cerebrovascular Center Yokohama Japan
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Yoshida Masaaki
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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