A New Mouse Model with Cochleo-Saccular Type Inner Ear Defects
スポンサーリンク
概要
- 論文の詳細を見る
We found a new inner ear mutant exhibiting abnormal behavior, such as circling and head shaking, in a breeding stock of SJL/J mice. The traits are inherited in a simple autosomal-recessive fashion. Animals homozygous for the responsible gene, designated cosa, show no startle response to sounds and an inability to swim. In the inner ears of cosa/cosa homozygous, but not +/cosa heterozygous adults, histopathological features of severe damage that are typical for `cochleo-saccular or `spotting mutants have been demonstrated. We suggest here that the abnormal mice carry a mutation of a gene that is developmentally switched on in the early stages of development and is involved in endolymph homeostasis.
- 社団法人 日本実験動物学会の論文
- 2001-10-01
著者
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ODA Sen-ichi
Laboratory of Animal Management and Resources, Graduate School of Bioagricultural Sciences, Nagoya U
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Yonezawa Satoshi
Institute for Developmental Research, Aichi Human Service Center
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Oda Sen-ichi
Graduate School Of Agricultural Sciences Nagoya University
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Oda Sen-ichi
Laboratory Of Animal Management & Resources Graduate School Of Bio-agricultural Sciences Nagoya
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Oda Sen-ichi
The School Of Agricultural Sciences Nagoya University
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Oda Sen-ichi
Laboratory Of Animal Management And Resources Graduate School Of Bio-agricultural Sciences Nagoya Un
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Oda Sen-ichi
Lab. Animal Management & Resources Nagoya Univ.
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Oda Sen-ichi
Nagoya Univ.
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Oda Sen-ichi
Laboratory Of Zoology Faculty Of Agriculture Graduate School Kyushu University
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HANAI Atsuko
Institute for Developmental Research, Aichi Human Service Center
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MASAKI Shigeo
Institute for Developmental Research, Aichi Human Service Center
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Oda Senichi
Laboratory Of Animal Management And Resources Division Of Biosphere Resource Sciences Nagoya Univers
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Hanai A
Institute For Developmental Research Aichi Human Service Center
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Masaki Shigeo
Institute For Developmental Research Aichi Human Service Center
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HANAI Atsuko
Embryology
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MASAKI Shigeo
Biochemistry, Institute for Developmental Research, Aichi Human Service Center
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YONEZAWA Satoshi
Embryology
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Ohta Sho
米国
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Yonezawa S
Institute For Developmental Research Aichi Human Service Center
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Oda Sen-ichi
School Of Agricultural Sciences Nagoya University
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Masaki S
Institute For Developmental Research Aichi Human Service Center
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