Taltirelin Improves Motor Ataxia Independently of Monoamine Levels in Rolling Mouse Nagoya, a Model of Spinocerebellar Atrophy(Pharmacology)
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概要
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To examine the relationship between motor ataxia and monoamine levels in the central nervous system, the contents and concentrations of noradrenaline (NA), dopamine (DA) and serotonin (5-HT) in the cerebellum, brain stem and spinal cord were measured in rolling mouse Nagoya (RMN), a murine model of spinocerebellar atrophy. The tissue weight of the cerebellum and spinal cord, but not that of the brain stem was significantly lower in RMN than in the control group. In RMN, the NA content of the brain stem and spinal cord, but not the cerebellum were decreased relative to the control, and the concentration of NA in the spinal cord was also lower, but not significant. The DA and 5-HT contents in each tissue did not differ from those of the control, but the concentrations of monoamines, except for DA, were elevated in the brain stem and spinal cord in RMN. In particular, the concentrations of NA, DA and 5-HT in the cerebellum were significantly increased in RMN. Repeated administration of tartilerin hydrate, an analog of thyrotropin-releasing hormone, improved the ataxia of RMN, and elicited no obvious changes in either monoamine content or concentration of cerebellum, brain stem and spinal cord. These results indicate that the concentration of DA, as well as NA and 5-HT, increased in the RMN cerebellum, and that tartilerin improves the motor function of these mice via mechanisms other than changes in the levels of NA, DA and 5-HT in the central nervous system.
- 公益社団法人日本薬学会の論文
- 2005-12-01
著者
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Oda Satoko
東邦大学 医学部解剖学
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Kimura Satoko
Laboratory Of Cns Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City University
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Kimura Satoko
名古屋市立大学 薬学研究科中枢神経機能薬理学分野
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NAKAMURA Tomoka
Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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HONDA Motoko
Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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TANABE Mitsuo
Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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ODA Senichi
Laboratory of Animal Management and Resources, Division of Biosphere Resource Sciences, Nagoya Unive
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ONO Hideki
Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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Oda Sen-ichi
Graduate School Of Agricultural Sciences Nagoya University
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Oda Sen-ichi
Laboratory Of Animal Management & Resources Graduate School Of Bio-agricultural Sciences Nagoya
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Oda S
Nagoya Univ. Nagoya Jpn
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Oda Sen-ichi
The School Of Agricultural Sciences Nagoya University
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Oda Sen-ichi
Laboratory Of Animal Management And Resources Graduate School Of Bio-agricultural Sciences Nagoya Un
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Oda Sen-ichi
Laboratory Of Animal Management & Resources Graduate School Of Bioagricultural Sciences Nagoya U
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Oda Sen-ichi
Lab. Animal Management & Resources Nagoya Univ.
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Oda Sen-ichi
Nagoya Univ.
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Oda Sen-ichi
Laboratory Of Zoology Faculty Of Agriculture Graduate School Kyushu University
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Ono Hideki
Laboratory Of Cns Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City University
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Oda Senichi
Laboratory Of Animal Management And Resources Division Of Biosphere Resource Sciences Nagoya Univers
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Honda Motoko
Laboratory Of Cns Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City University
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Oda Sen-ichi
Graduate School Of Bio-agricultural Science Nagoya University
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Tanabe Mitsuo
名古屋大学 薬学研究科中枢神経機能薬理学
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Tanabe Mitsuo
Laboratory Of Cns Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City University
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Nakamura Tomoka
Laboratory Of Cns Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City University
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Ohta Sho
米国
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Oda Sen-ichi
School Of Agricultural Sciences Nagoya University
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Ono Hideki
Laboratory Of Cns Pharmacology Graduate School Of Pharmaceutical Sciences
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Tanabe Mitsuo
Laboratory Of Pharmacology School Of Pharmacy Kitasato University
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