Spinorphin, an Endogenous Inhibitor of Enkephalin-Degrading Enzymes, Potentiates Leu-Enkephalin-Induced Anti-allodynic and Antinociceptive Effects in Mice
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概要
- 論文の詳細を見る
Spinorphin (LVVYPWT) has been isolated from the bovine spinal cord as an endogenous inhibitor of enkephalin-degrading enzymes. It has been reported that spinorphin has an antinociceptive effect, inhibitory effect on contraction of smooth muscle and anti-inflammatory effect. In the present study, the effects of leu-enkephalin and spinorphin on allodynia and mechanical and thermal nociceptions were examined in vivo using mice. Intrathecal (i.t.) administration of leu-enkephalin or spinorphin inhibited the allodynia induced by intrathecal nociceptin in a dose-dependent manner. Furthermore, spinorphin enhanced the inhibitory effect of enkephalin on allodynia induced by nociceptin. Naloxone antagonized both inhibitory effects of leu-enkephalin and spinorphin, suggesting that the endogenous opioidergic system can modulate allodynia. Intracerebroventricular (i.c.v.) administration of leu-enkephalin increased the nociceptive threshold of heat or mechanical stimulation to a mouse. Although i.c.v. administration of spinorphin had no effect on the threshold of heat or mechanical stimulation, spinorphin enhanced and prolonged the antinociceptive effect of leu-enkephalin. The enhancement of spinorphin on the antinociception produced by leu-enkephalin was reversed by pretreatment with naloxone. From these results, it is suggested that the effects of spinorphin on enkephalin-induced anti-allodynic and antinociceptive effects are due to inhibition of enkephalin-degrading enzymes.
- 社団法人 日本薬理学会の論文
- 2001-12-01
著者
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YAMAMOTO Yukio
Departments of Microbiology, Hamamatsu Medical Center
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HONDA Motoko
Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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ONO Hideki
Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
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Ono Hideki
Laboratory Of Cns Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City University
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Honda Motoko
Laboratory Of Cns Pharmacology Graduate School Of Pharmaceutical Sciences Nagoya City University
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Honda Motoko
Laboratory Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Okutsu Hiroko
Laboratory Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Matsuura T
Laboratory Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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MATSUURA Tomoyuki
Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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MIYAGI Tomohiro
Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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HAZATO Tadahiro
Department of Molecular Oncology, The Tokyo Metropolitan Institute of Medical Science
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Hazato Tadahiro
Department Of Molecular Oncology The Tokyo Metropolitan Institute Of Medical Science
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Miyagi Tomohiro
Laboratory Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Yamamoto Yukio
Department Of Agricultural Chemistry Faculty Of Agriculture Nagoya University
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Yamamoto Y
Department Of Molecular Oncology The Tokyo Metropolitan Institute Of Medical Science
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Ono Hideki
Laboratory Of Pharmacology Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Ono Hideki
Laboratory Of Cns Pharmacology Graduate School Of Pharmaceutical Sciences
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