Mapping of jog Locus to the Region between D6Mit104 and D6Mit336 on Mouse Chromosome 6

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概要

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• The joggle mouse is a recessive ataxic mutant carrying an unknown mutation in a C3H/He (C3H)-derived chromosomal segment. Taking advantage of the mouse genome database, we selected 127 DNA microsatellite markers showing heterozygosity between C3H and C57BL/6J (B6) and a first round of screening for the joggle mutation was performed on B6-jog/+ partial congenic mice (N4). We identified 4 chromosomal regions in which 13 microsatellite markers show heterozygosity between C3H and B6. Then, we analyzed the genotype of these 4 chromosomal regions in mice that showed the joggle phenotype and mapped the jog locus between markers D6Mit104 (111.4 Mb) and D6Mit336 (125.1 Mb) (an interval of 13.7 Mb) on chromosome 6. By using a partial congenic strain together with the mouse genome database, we successfully mapped the chromosomal localization of the jog locus much more efficiently than by conventional linkage analysis.

• 社団法人　日本実験動物学会の論文

著者

• ODA Sen-ichi

  Laboratory of Animal Management and Resources, Graduate School of Bioagricultural Sciences, Nagoya U

• OHNO Tamio

  Institute for Laboratory Animal Research, Nagoya University School of Medicine

• Takagishi Yoshiko

  Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya Universi

• MURATA Yoshiharu

  Department of Teratology and Genetics, Research Institute of Environmental Medicine, Nagoya Universi

• Takagishi Yoshiko

  名古屋大学環境医学研究所 循環器学

• SUN Xiao-yang

  Department of Genetics, Division of Stress Adaptation and Protection, Research Institute of Environm

• CHEN Zi-yan

  Laboratory of Animal Management & Resources, Graduate School of Bioagricultural Sciences, Nagoya Uni

• KANOU Yasuhiko

  Department of Genetics, Division of Stress Adaptation and Protection, Research Institute of Environm

• HAYASHI Yoshitaka

  Department of Genetics, Division of Stress Adaptation and Protection, Research Institute of Environm

• Murata Yoshiharu

  Department Of Civil Engineering College Of Engineering Nihon University

• Ohno Tamio

  Institute For Laboratory Animal Research Graduate School Of Medicine Nagoya University

• Kanou Yasuhiko

  Department Of Bioinformation Analysis Research Institute Of Environmental Medicine Nagoya University

• Takagishi Yoshiko

  Department Of Anatomy Mie University School Of Medicine

• Oda Sen-ichi

  Laboratory Of Animal Management & Resources Graduate School Of Bio-agricultural Sciences Nagoya

• Hayashi Yoshitaka

  Department Of Applied Physics And Chemistry Fukui Institute Of Technology

• SUN Xiao-yang

  Department of Genetics, Division of Stress Adaptation and Protection, Research Institute of Environmental Medicine, Nagoya University

• TAKAGISHI Yoshiko

  Department of Genetics, Division of Stress Adaptation and Protection, Research Institute of Environmental Medicine, Nagoya University

• CHEN Zi-yan

  Laboratory of Animal Management & Resources, Graduate School of Bioagricultural Sciences, Nagoya University

• ODA Sen-ichi

  Laboratory of Animal Management & Resources, Graduate School of Bioagricultural Sciences, Nagoya University

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