Change in Ucp1 mRNA Expression Following Long-Term Cold Exposure under Normal or High-Fat Diet Regimes in the Cold-Intolerant Mammal, Suncus murinus
スポンサーリンク
概要
- 論文の詳細を見る
The house musk shrew (Suncus murinus), or suncus, is a unique experimental mammal that is cold intolerant. However, even basic knowledge of brown adipose tissue (BAT), which is important for non-shivering thermogenesis (NST), is minimal. Therefore, we exposed suncus for 18 days to mild cold temperatures (8-14°C) and/or a high-fat diet, which are factors that increase NST, and measured two mRNAs that are critical for NST in BAT, uncoupling protein 1 (Ucp1) and type II 5'-deiodinase (D2). Neither mild cold exposure nor a high-fat diet alone induced up-regulation of the mRNAs. However, combinations of cold exposure and high-fat diet significantly increased both mRNAs. Therefore, cold intolerance in suncus may be partly caused by dietary components.
著者
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Murata Yoshiharu
Department Of Civil Engineering College Of Engineering Nihon University
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SUZUKI Daisuke
Laboratory of Animal Management & Resources, Graduate School of Bio-Agricultural Sciences, Nagoya Un
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Oda Sen-ichi
Laboratory Of Animal Management & Resources Graduate School Of Bio-agricultural Sciences Nagoya
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ODA Sen-ichi
Laboratory of Animal Management & Resources, School of Bio-Agricultural Sciences
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