Determination of Cathepsins D and E in Various Tissues and Cells of Rat, Monkey, and Man by the Assay with β-Endorphin and Substance P as Substrates
スポンサーリンク
概要
- 論文の詳細を見る
We developed a new method for the assay of cathepsins D and E. The method was based on the different hydrolytic activities of cathepsins D and E against β-endorphin and substance P. The method was applied to the determination of the levels of cathepsins D and E in various tissues and cells of rat, monkey, and man, and was clarified to be much more specific, sensitive, and quantitative than the ordinary hemoglobin-digestion method. The levels of cathepsin D were high in adrenal and spleen, and the levels of cathepsin E were high in gastrointestinal tissues, bone marrow, and lymph node. The variations in level were much wider in the case of cathepsin E than in the case of cathepsin D. This might reflect that cathepsin D is a house-keeping lysosomal enzyme in a variety of cells and cathepsin E is involved in the physiological activities of certain types of tissues and cells.
- 社団法人日本動物学会の論文
- 1996-10-15
著者
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MORIYAMA Akihiko
Division of Biomolecular Science, Institute of Natural Sciences, Nagoya City University
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Kato T
Institute Of Reproduction And Endocrinology Meiji University
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Kato Tomomi
Biological Laboratory Center For Natural Sciences Kitasato University
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KAGEYAMA Takashi
Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University
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Kato Taiji
Department Of Bioregulation Biomedical Institute Nagoya City University Medical School
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Yonezawa Satoshi
Institute for Developmental Research, Aichi Human Service Center
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Moriyama Akihiko
Division Of Biomolecular Science Institute Of Natural Sciences Nagoya City University
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Moriyama Akihiko
Department Of Life Science Institute Of Natural Sciences Nagoya City University
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Sano Mamoru
Department Of Biology Faculty Of Medicine Kyoto Prefectural University Of Medicine
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Sano Mamoru
Institute For Developmental Research Aichi Colony
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Moriyama A
Nagoya City Univ. Aichi Jpn
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Yonezawa S
Institute For Developmental Research Aichi Human Service Center
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Yonezawa Satoshi
Institute For Developmental Research Aichi Human Service Center
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Takahashi Kyoko
Department Of Food Science And Nutrition School Of Human Environmental Sciences Mukogawa Women'
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KATO Taiji
Department of Biochemistry, Nagoya City University Medical School
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