Molecular Cloning and Characterization of Porcine Homeodomain Transcription Factor Msx1
スポンサーリンク
概要
- 論文の詳細を見る
We cloned a porcine ortholog of homeodomain transcription factor Msx1 from the porcine pituitary cDNA library. The amino acid sequence of Msx1 shows high conservation among mammalian species. RT-PCR for porcine fetal and postnatal pituitaries showed that Msx1 is already expressed at early fetal day 40, decreases to a low level before birth and then remarkably decreases after birth. On the other hand, Msx1 expression was observed in all pituitary-derived cell line tested, with most in a gonadotrope lineage LβT4. Transfection assay demonstrated that Msx1 markedly repressed the basal αGsu and Fshβ gene expression, while Lhβ expression was affected slightly. Taken together, Msx1 may play a role in repressing gene expression in the fetal and postnatal periods.
- 日本繁殖生物学会の論文
- 2009-06-01
著者
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Ishikawa Akio
Division Of Life Science Graduate School Of Agriculture Meiji University
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Kato T
Institute Of Reproduction And Endocrinology Meiji University
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KATO Yukio
Division of Pharmaceutical Sciences, Graduate School of Natural Science & Technology
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SUSA Takao
Division of Life Science, Graduate School of Agriculture, Meiji University
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KATO Takako
Institute of Reproduction and Endocrinology, Meiji University
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SANO Akiko
Division of Life Science, Graduate School of Agriculture, Meiji University
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Sato Takanobu
Lab. Of Molecular Biology And Gene Regulation Graduate School Of Agriculture
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Susa Takao
明治大学 農学部生命科学科
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Kato Yukio
Department Of Dental And Medical Biochemistry Hiroshima University Graduate School Of Biomedical Sci
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Kato Y
Meiji Univ. Kanagawa Jpn
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Aikawa Satoko
Division Of Life Science Graduate School Of Agriculture Meiji University
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Susa Takao
Division Of Life Science Graduate School Of Agriculture Meiji University
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Kato Yukio
Division Of Life Science Graduate School Of Agriculture Meiji University
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Sano Akiko
Div. Of Life Sci. Graduate School Of Agriculture Meiji Univ.
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Kato T
Waseda Univ. Tokyo Jpn
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Sato T
Inst. Of Reproduction And Endocrinology Meiji Univ.
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Sano Akiko
Division Of Life Science Graduate School Of Agriculture Meiji University
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Kato Takako
Institute Of Reproduction And Endocrinology Meiji University
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Kato Yukio
Department Of Dental And Medical Biochemistry Hiroshima University Graduate School Of Biomedical Sci
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Kato Takako
Institute Of Plasma Physics Nagoya University
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Kato Y
Department Of Dental And Medical Biochemistry Hiroshima University Graduate School Of Biomedical Sci
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