Involvement of carnitine/organic cation transporter OCTN2 (SLC22A5) in distribution of its substrate carnitine to the heart
スポンサーリンク
概要
- 論文の詳細を見る
出版者許諾要件で機関リポジトリでの全文は非公開.This study was designed to clarify the pharmacological role of carnitine/ organic cation transporter (Octn) family members in mouse heart. Immunohistochemical analysis revealed that Octn1 was exclusively expressed on endothelial cells in blood vessels. Octn2 was detected on the plasma membrane of cardiac muscle cells by immunoelectron microscopy. Octn3 was not detected in the heart. Integration plot analysis showed that coadministration of unlabeled L-carnitine reduced distribution of L-[3H]carnitine to the heart. L-[3H]Carnitine uptake in heart slices was reduced by carnitine analogs and various Octn2 substrates. L-[3H]Carnitine uptake by heart slices from juvenile visceral steatosis (jvs) mice, which have a hereditary octn2 gene deficiency, was negligible. Distribution of [3H]quinidine, another Octn2 substrate, to the heart was not reduced by L-carnitine, and [3H]quinidine uptake in heart slices was Na+-independent and inhibited by cationic drugs, but not carnitine analogs. [3H]Quinidine uptake by heart slices from jvs mice was similar to that of wild-type mice. These results demonstrate that OCTN2 is functionally expressed on the plasma membrane of muscle cells and is involved in distribution of carnitine to the heart. Some mechanism(s) other than OCTN2 is involved in the distribution of quinidine to the heart.
- Japanese Society for the Study of Xenobiotics = 日本薬物動態学会の論文
- 2008-06-25
著者
-
Tsuji Akira
金沢大学 自然科学研究科創剤科学
-
Iseki Shoichi
Kanazawa Univ. Kanazawa Jpn
-
Iseki Shoichi
Department Of Histology And Embryology Graduate School Of Medical Science Kanazawa University
-
Iseki Shoichi
Department Of Anatomy Kanazawa University School Of Medicine
-
Wakayama Tomohiko
Kanazawa Univ. Kanazawa Jpn
-
Wakayama Tomohiko
Department Of Histology And Embryology Graduate School Of Medical Science Kanazawa University
-
Wakayama T
Department Of Anatomy And Reproductive Cell Biotogy Miyazaki Medicat Couege
-
Wakayama Tomohiko
宮崎医科大学 第1解剖
-
Wakayama Tomohiko
金沢大学 自然科学研究科薬物動態学
-
IWATA Daisuke
Division of Pharmaceutical Sciences, Graduate School of Natural Science & Technology
-
KATO Yukio
Division of Pharmaceutical Sciences, Graduate School of Natural Science & Technology
-
SAI Yoshimichi
Division of Pharmaceutical Sciences, Graduate School of Natural Science & Technology
-
KUBO Yoshiyuki
Division of Pharmaceutical Sciences, Graduate School of Natural Science & Technology
-
TSUJI Akira
Division of Pharmaceutical Sciences, Graduate School of Natural Science & Technology
-
Wakayama Tomohiko
Department Of Anatomy And Reproductive Cell Biotogy Miyazaki Medicat Couege
-
Wakayama Tomohiko
Department Of Anatomy School Of Medicine Kanazawa Univeristy
-
Kato Yukio
Department Of Dental And Medical Biochemistry Hiroshima University Graduate School Of Biomedical Sci
-
Kato Y
Meiji Univ. Kanagawa Jpn
-
Tsuji A
金沢大学 自然科学研究科創剤科学
-
Iwata Daisuke
Division Of Pharmaceutical Sciences Graduate School Of Natural Science & Technology
-
Kubo Yoshiyuki
金沢大学 自然科学研究科創剤科学
-
Sai Yoshimichi
Division Of Pharmaceutical Sciences Graduate School Of Natural Science & Technology
-
Kato Yukio
Division Of Life Science Graduate School Of Agriculture Meiji University
-
Tsuji Akira
Division Of Pharmaceutical Sciences Graduate School Of Natural Science And Technology Kanazawa Unive
-
Kato Yukio
Department Of Dental And Medical Biochemistry Hiroshima University Graduate School Of Biomedical Sci
-
Kubo Yoshiyuki
Division Of Pharmaceutical Sciences Graduate School Of Natural Science And Technology Kanazawa Unive
-
Kato Yukio
金沢大学 自然科学研究科創剤科学
-
Iseki Shoich
Department of Histology and Embryology, Graduate School of Medical Science, Kanazawa University
-
Kubo Yoshiyuki
Faculty Of Pharmacy Institute Of Medical Pharmaceutical And Health Sciences Graduate School Of Medic
-
Sai Y
Division Of Pharmaceutical Sciences Graduate School Of Natural Science & Technology
関連論文
- ＜Symposium I＞Vascular endothelial growth factor（ VEGF） expression is negatively regulated by basic-helix-loop-helix（ bHLH）transcription factor DEC2
- ＜Symposium I＞Roles of DEC1 and DEC2 in the core loop of the circadian clock, and clock outputs to metabolism
- Mechanical Regulation of Terminal Chondrocyte Differentiation via RGD-CAP/βig-h3 Induced by TGF-β
- Differential Expression of Ezrin and CLP36 in the Two Layers of Syncytiotrophoblast in Rats
- Involvement of carnitine/organic cation transporter OCTN2 (SLC22A5) in distribution of its substrate carnitine to the heart
- A time- and cost-saving method of producing rat polyclonal antibodies
- IIA-09 The cost- and time-saving method of producing polyclonal antibodies(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Molecular Cloning of Paired Related Homeobox 2 (Prx2) as a Novel Pituitary Transcription Factor
- Regulation of Porcine Pituitary Glycoprotein Hormone Alpha Subunit Gene with LIM-Homeobox Transcription Factor Lhx3
- Molecular Cloning and Characterization of Porcine Homeodomain Transcription Factor Msx1
- Cloning and Characterization of Porcine CArG Binding Factor A Expression in the Anterior Pituitary
- NEURONATIN LOCALIZES IN SECRETORY GRANULE OF GONADOTROPE AND IS REGULATED BY STEROID HORMONES
- DNA-BINDING CHARACTERISTICS OF TRANSCRIPTION FACTORS EXPRESSING IN THE ANTERIOR PITUITARY GRAND
- A NOVEL PITUITARY TRANSCRIPTION FACTOR, PRX2 WAS ACTIVATED BY GNRH AND PLAYS SYNERGISTICALLY WITH EGR-1 ON LUTEINIZING HORMONE BETA SUBUNIT GENE
- Analysis of Genes Expressed During Porcine Fetal Pituitary Development by Suppressive Subtraction Hybridization
- Expression of Porcine FSHβ Subunit Promoter-driven Herpes Simplex Virus Thymidine Kinase Gene in Transgenic Rats
- ULTRASTRUCTURAL ABNORMALITY OF SPERMATOZOA AND AGE-DEPENDENT LOSS OF SPERMATOGENESIS IN TRANSGENIC RAT
- A NOVEL PITUITARY TRANSCRIPTION FACTOR, PAIRED-RELATED HOMEOBOX FACTOR 2, REGULATES GONADOTROPIN SUBUNIT GENES
- DISTINCTION BETWEEN LIM HOMEODOMAIN TRANSCRIPTION FACTORS LHX2 AND LHX3
- IN VITRO SELECTION OF PITUITARY TRANSCRIPTION FACTOR PROP-1 RESPONSIVE ELEMENTS
- TRANSCRIPTION FACTORS PROP-1, LHX2 AND LHX3 ACTIVATE FSHβ GENE EXPRESSION
- EXPRESSION OF THE PITUITARY GLYCOPROTEIN HORMONE a-SUBUNIT GENE BY LIM-HOMEODOMAIN-2 AND COFACTOR, cLim2 IN CHO CELLS(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- ONTOGENY OF cLim2 GENE EXPRESSION IN PORCINE PITUITARY AND ROLE IN LHβ GENE EXPRESSION(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- TRANSCRIPTIONAL CONTROL BY GNRH FOR THE PORCINE GTHα-SUBUNIT GENE IN LβT2 CELL(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Complementary DNA Sequence of Chicken Thyroid-Stimulating Hormone (TSH) β Subunit
- Molecular Cloning of Quail Thyroid-Stimulating Hormone (TSH) β Subunit
- Gene Expression in Individual Bovine Somatic Cell Cloned Embryos at the 8-cell and Blastocyst Stages of Preimplantation Development
- L-Type Fatty Acid Binding Protein Transgenic Mouse as a Novel Tool to Explore Cytotoxicity to Renal Proximal Tubules
- Prulifloxacin (PUFX) の肝臓への取り込み機構の解明
- Conditioning Regimen of Melphalan, Fludarabine and Total Body Irradiation in Unmanipulated HLA Haploidentical Stem Cell Transplantation Based on Feto-maternal Tolerance
- Adenocarcinomatosis of the Bone Marrow and Secondary Acute Myeloid Leukemia
- Function of Uptake Transporters for Taurocholate and Estradiol 17β-D-Glucuronide in Cryopreserved Human Hepatocytes
- Primary Cutaneous Diffuse Large B Cell Lymphoma : A Clinically Aggressive Case
- Effective and Safe Interferon Treatment for Japanese Patients With Chronic Myelogenous Leukemia Relapse After Bone Marrow Transplantation
- Visualization of the Specific Gene Transcription in the Nucleus with a Novel In Situ RNase Protection Method
- Protein Expression and Cell Organelle Behavior in Spermatogenic Cells
- The Expression and Cellular Localization of the Sperm Flagellar Protein MC31/CE9 in the Rat Testis : Possible Posttranscriptional Regulation during Rat Spermiogenesis
- Urinary Trypsin Inhibitor : Production in the Liver and Reabsorption in the Kidney of the Rat
- P-21 Expression and Localization of Urinary Trypsin Inhibitor in the Rat Embryo
- Coexpression of menin and JunD during the duct cell differentiation in mouse submandibular gland
- IIB-20 A novel protein from mouse submandibular gland whose expression is downregulated by androgens(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Expression of the Adhesion Molecule Spermatogenic Immunoglobulin Superfamily (SgIGSF) in Mouse Tissues.
- Role of the spermatogenic-Sertoli cell interaction through cell adhesion molecule-1 (CADM1) in spermatogenesis
- Expression and localization of the cell adhesion molecule SgIGSF during regeneration of the olfactory epithelium in mice
- Effects of Heavy Oil from the Nakhodka on Hepatic and Pulmonary Enzymes of Mice(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)
- Immunohistochemical localization of vascular endothelial growth factor in the endocrine glands of the rat
- A novel temperature sensitive cell line (Tpit/E and Tpit/F1) established from the anterior pituitary gland of T - antigen transgenic mouse
- EXPRESSION OF BIOLOGICALLY ACTIVE PORCINE FOLLICLESTIMULATING HORMONE IN INSECT CELLS USING A BACULOVIRUS VECTOR AND THE ESTABLISHMENT OF AN ANTI-SERUM
- PERIOD1 is an Anti-apoptotic Factor in Human Pancreatic and Hepatic Cancer Cells
- Effect of the Timing of First Cleavage on In vitro Developmental Potential of Nuclear-Transferred Bovine Oocytes Receiving Cumulus and Fibroblast Cells
- Na /H Exchanger 3 affects transport property of H /oligopeptide transporter 1
- Involvement of Multiple Transport Systems in the Disposition of an Active Metabolite of a Prodrug-type New Quinolone Antibiotic, Prulifloxacin
- Mutagenicity of Surface Sand in Park Sandboxes
- Recovery Rate in the Concentration of Semivolatile Polycyclic Aromatic Hydrocarbon (PAH) Solutions
- Enhancement of the Receptor Binding and Nb2 Proliferation Activities of Rat Prolactin by Site-Directed Mutagenesis
- Increased Thermo-Stability of Rat Prolactin after Replacing Glutamic Acid at Position 118 by Lysine
- Involvement of Transcription Factor Pit-1/GHF-1 in Stimulation of Growth Hormone-Releasing Factor
- NOVEL TRANSCRIPTION FACTOR IN THE PORCINE ANTERIOR PITUITARY GLAND THAT INTERACTS WITH LEUCINE-ZIPPER OF cJUN
- GENES EXPRESSED IN THE ANTERIOR PITUITARY GLAND
- MOLECULAR CLONING OF PIT-1 cDNA AND THE REGULATION OF ITS mRNA LEVEL BY THE GROWTH HORMONE-RELEASING FACTOR
- MOLECULAR CLONING OF cDNA THAT ENCODES THE β SUBUNIT OF TELEOST THYROTROPIN FROM THE GOLDFISH
- CLONING OF PORCINE ANTERIOR PITUITARY NUCLEAR FACTORS THAT INTERACT WITH THE bZIP DOMAIN OF cJUN BY A TWO-HYBID SYSTEM IN YEAST CELLS
- Reorganization of isolated chondrocytes into growth plate-like tissues in pelleted cultures
- Half-way Achievement With "DMPK Globalization Committee" ; What Had Been and What Is to Be Done for Further Globalization
- PDZ蛋白質PDZK1の遺伝子変異は複数のトランスポーターの機能もしくは発現に影響を及ぼす
- 30-II-07 Expression of the transcription factor JunD in the diffferentiation of the duct system of mouse submandibular gland(THE JOINT MEETING OF THE 44TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY AND THE 35TH ANNUAL MEETING
- The role of cyclic AMP response element-binding protein in the differentiation of granular convoluted tubule cells in the rat submandibular gland
- In situ hybridization detection of the mRNA for growth factors and their receptors in the rodent organs
- Antisense oligodeoxyribonucleotide targeting cAMP response element-binding protein inhibits growth of rat submandibular gland in vitro
- II-B-17 Co-expression of menin with JunD in the duct system of mouse submandibular gland(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- A-9 Immunohistochemical localization of Vascular endothelial growth factor (VEGF) in the endocrine glands of the rat
- Functional regions of organic cation/carnitine transporter OCTN2 (SLC22A5): Roles in carintine recognistion
- Evaluation of Blood-Brain Barrier Transporters by Co-culture of Brain Capillary Endothelial Cells with Astrocytes
- Design and Synthesis of Peptides Passing through the Blood-Brain Barrier
- Study on Peptide Transport across Tissue Cell Menbrane by Adsorptive-Mediated Transcytosis
- Carrier-Mediated Uptake of Grepafloxacin, a Fluoroquinolone Antibiotic, by the Isolated Rat Lung Cells
- The Recent Progress on Nuclear Transfer in Mammals
- Prominent Expression of Spinocerebellar Ataxia Type-1 (SCA1) Gene Encoding Ataxin-1 in LH-Producing Cells, LβT2
- Expression of Porcine FSHβ Subunit Promoter-driven Herpes Simplex Virus Thymidine Kinase Gene in Transgenic Rats
- Direct evidence for efficient transport and minimal metabolism of L-cephalexin by oligopeptide transporter 1 in budded baculovirus fraction
- Co-expression of NGF and Its High-affinity Receptor TrkA in the Rat Carotid Body Chief Cells
- ウシ体細胞核移植卵由来胚盤胞の凍結保存:発育ステージが凍結融解後の生存性に及ぼす影響
- Pharmacokinetics and Mechanism of Intestinal Absorption of JBP485 in Rats
- PDZK1 Regulates Organic Anion Transporting Polypeptide Oatpla in Mouse Small Intestine
- Molecular Cloning of LIM Homeodomain Transcription Factor Lhx2 as a Transcription Factor of Porcine Follicle-Stimulating Hormone Beta Subunit (FSHβ) Gene
- Compensatory upregulation of myelin protein zero-like 2 expression in spermatogenic cells in cell adhesion molecule-1-deficient mice
- Detection of Human Herpesviruses (HHVs) in Semen of Human Male Infertile Patients