Expression and localization of the cell adhesion molecule SgIGSF during regeneration of the olfactory epithelium in mice
スポンサーリンク
概要
- 論文の詳細を見る
Spermatogenic immunoglobulin superfamily (SgIGSF) is a cell adhesion molecule originally discovered in mouse testis. SgIGSF is expressed not only in spermatogenic cells but also in lung and liver epithelial cells and in neurons and glia of the central and peripheral nervous systems. In the present study, we examined the expression and localization of SgIGSF in mouse olfactory epithelium before and after transection of the olfactory nerves, by RT-PCR, Western blotting and immunohistochemistry. In normal olfactory mucosa, SgIGSF showed 100 kDa in molecular weight, which was identical with that in the lung but different from that in the brain. SgIGSF was expressed on the membrane of all olfactory, sustentacular and basal cells, but more abundantly in the apical portions of the olfactory epithelium where the dendrites of olfactory cells are in contact with sustentacular cells. After olfactory nerve transection, mature olfactory cells disappeared in 4 days but were regenerated around 7-15 days by proliferation and differentiation of basal cells into mature olfactory cells through the step of immature olfactory cells. During this period, both the mRNA and protein for SgIGSF showed a transient increase, with peak levels at 7 days and 11 days, respectively, after the transection. Immunohistochemistry showed that the enriched immunoreactivity for SgIGSF at 7-11 days was localized primarily to the membrane of immature olfactory cells. These results suggested that, during regeneration of the olfactory epithelium, the adhesion molecule SgIGSF plays physiological roles in differentiation, migration, and maturation of immature olfactory cells. (C) 2007 The Japan Society of Histochemistry and Cytochemistry.
- 日本組織細胞化学会の論文
著者
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塚谷 才明
Department of Otolaryngology, Kanazawa University School of Medicine
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古川 仭
Department of Otolaryngology, Kanazawa University School of Medicine
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Iseki Shoichi
Department Of Histology And Embryology Graduate School Of Medical Science Kanazawa University
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Iseki Shoichi
Department Of Anatomy Kanazawa University School Of Medicine
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Wakayama Tomohiko
Department Of Histology And Embryology Graduate School Of Medical Science Kanazawa University
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Wakayama Tomohiko
Department Of Anatomy And Reproductive Cell Biotogy Miyazaki Medicat Couege
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FURUKAWA Mitsuru
Department of Otolaryngology, School of Medicine, Kanazawa University
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Tsukioka Fusae
Department of Histology and Embryology, Graduate School of Medical Science, Kanazawa University
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Tsukatani Toshiaki
Department of Otorhinolaryngology, Graduate School of Medical Science, Kanazawa University
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Miwa Takaki
Department of Otorhinolaryngology, Graduate School of Medical Science, Kanazawa University
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Miwa Takaki
Department Of Otorhinolaryngology Graduate School Of Medical Science Kanazawa University
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Tsukioka Fusae
Department Of Histology And Embryology Graduate School Of Medical Science Kanazawa University:depart
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FURUKAWA Mitsuru
Kanazawa University
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Tsukatani Toshiaki
Department Of Otolaryngology School Of Medicine Kanazawa University
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Furukawa Mitsuru
Department Of Orthopedic Surgery Keio University School Of Medicine
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井関 尚一
Department of Anatomy, School of Medicine, Kanazawa Univeristy
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若山 友彦
Department of Anatomy, School of Medicine, Kanazawa Univeristy
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三輪 髙喜
Department of Otorhinolaryngology, Graduate School of Medical Science, Kanazawa University
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