Role of the spermatogenic-Sertoli cell interaction through cell adhesion molecule-1 (CADM1) in spermatogenesis
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概要
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最終稿を登録可能.Endocrine and local secretory factors have long been known to be required for spermatogenesis. Evidence has been accumulating in recent years indicating that direct contact between spermatogenic and Sertoli cells is also required for spermatogenesis. Cell adhesion molecules of various types have been found in the mammalian testis that are expressed in spermatogenic and/or Sertoli cells and involved in homophilic and/or heterophilic binding. We have cloned a novel cell adhesion molecule, cell adhesion molecule-1 (CADM1), also known as immunoglobulin superfamily 4A or spermatogenic immunoglobulin superfamily, from the mouse testis. CADM1 belongs to the immunoglobulin superfamily and is composed of three immunoglobulin-like domains, a transmembrane domain, and a short intracellular domain. In the seminiferous epithelium, CADM1 is expressed in intermediate spermatogonia through to early pachytene spermatocytes as well as in elongating spermatids - but not in round spermatids, mature spermatozoa, or Sertoli cells. One of the heterophilic binding partners of CADM1 has proven to be a poliovirus receptor, another member of the immunoglobulin superfamily that is expressed in Sertoli cells. Knockout mice for CADM1 develop male infertility due to defective spermatogenesis. These findings suggest that cell adhesion molecules between spermatogenic and Sertoli cells play essential roles in spermatogenesis. © Japanese Association of Anatomists 2009.
- Springer Japan / Japanese Association of Anatomists = 日本解剖学会の論文
- 2009-09-01
著者
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Iseki Shoichi
Department Of Histology And Embryology Graduate School Of Medical Science Kanazawa University
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Iseki Shoichi
Department Of Anatomy Kanazawa University School Of Medicine
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Wakayama Tomohiko
Department Of Histology And Embryology Graduate School Of Medical Science Kanazawa University
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Wakayama Tomohiko
Department Of Anatomy And Reproductive Cell Biotogy Miyazaki Medicat Couege
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