Conditioning Regimen of Melphalan, Fludarabine and Total Body Irradiation in Unmanipulated HLA Haploidentical Stem Cell Transplantation Based on Feto-maternal Tolerance

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概要

• 論文の詳細を見る

• Unmanipulated hematopoietic stem cell transplantation from haploidentical family donors is frequently associated with graft failure and severe graft-versus-host disease (GVHD). We employed a myeloablative conditioning regimen consisting of 125 mg/m2 of fludarabine, 140 mg/m2 of melphalan and TBI of 10 to 12 Gy for three patients. The donor in each case was a haploidentical two-loci HLA mismatch mother or son. Engraftment failure was observed in one patient. In the other two patients, engraftment was confirmed within 15 days after transplantation. Acute and chronic GVHD was observed, but was controllable in both cases. HLA mismatched transplantation based on feto-maternal tolerance may provide an alternative option for patients who do not have HLA-matched donors.

• 社団法人　日本内科学会の論文
• 2004-11-01

著者

• KATO Yukio

  Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sc

• SHIMADA Kazuyuki

  Department of Medicine, Jichi Medical University

• MORISHITA Yoshihisa

  Department of Hematology and Oncology JA Aichi Konan Kosei Hospital

• KOHNO Akio

  Department of Hematology and Oncology JA Aichi Konan Kosei Hospital

• NARIMATSU Hiroto

  Department of Hematology and Oncology, Nagoya University Graduate School of Medicine

• Ozeki Kazutaka

  愛知県厚生連昭和病院

• Ozeki Kazutaka

  Division Of Hematology And Oncology Ja Aichi Showa Hospital

• Ozeki Kazutaka

  Molecular Medicine Nagoya University Graduate School Of Medicine

• Kohno Akio

  愛知県厚生連昭和病院

• Kohno Akio

  Division Of Hematology And Oncology Ja Aichi Showa Hospital

• Kohno A

  Nagoya Univ. School Of Medicine Nagoya Jpn

• Kamiya Yoshikazu

  Department Of Hematology Meitetsu Hospital

• Kato Y

  Meiji Univ. Kanagawa Jpn

• Kunitomi Akane

  名鉄病院 血液内科

• Matsuno Yoshihiro

  Department Of Chemotherapy Tokyo Metropolitan Cancer And Infectious Diseases Center Komagome Hospita

• SAITO Shigeki

  Department of Hematology and Oncology, JA Aichi Showa Hospital

• Shimada Kazuyuki

  Department Of Hematology And Oncology Ja Aichi Showa Hospital

• Kohno Akio

  First Department Of Internal Medicine Nagoya University School Of Medicine

• Kato Yukio

  Department Of Applied Biological Science Tokyo University Of Science

• Morishima Yasuo

  Department Of Hematology And Chemotherapy

• Narimatsu Hiroto

  Department Of Hematology And Oncology Ja Aichi Showa Hospital

• Moriuchi Yukiyoshi

  Nagasaki Cml Study Group Nagasaki Jpn

• Shimada Kazuyuki

  Department Of Anatomy School Of Medicine Showa University

• Saito Shigeki

  Department Of Hematology And Oncology Ja Aichi Showa Hospital

• Kato Yukio

  Department Of Hematology And Oncology Ja Aichi Showa Hospital

• Morishima Yasuo

  Department Of Pathology And Oncology Institute Of Medical Science University Of Tokyo

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