Conditioning Regimen of Melphalan, Fludarabine and Total Body Irradiation in Unmanipulated HLA Haploidentical Stem Cell Transplantation Based on Feto-maternal Tolerance
スポンサーリンク
概要
- 論文の詳細を見る
Unmanipulated hematopoietic stem cell transplantation from haploidentical family donors is frequently associated with graft failure and severe graft-versus-host disease (GVHD). We employed a myeloablative conditioning regimen consisting of 125 mg/m2 of fludarabine, 140 mg/m2 of melphalan and TBI of 10 to 12 Gy for three patients. The donor in each case was a haploidentical two-loci HLA mismatch mother or son. Engraftment failure was observed in one patient. In the other two patients, engraftment was confirmed within 15 days after transplantation. Acute and chronic GVHD was observed, but was controllable in both cases. HLA mismatched transplantation based on feto-maternal tolerance may provide an alternative option for patients who do not have HLA-matched donors.
- 社団法人 日本内科学会の論文
- 2004-11-01
著者
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KATO Yukio
Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sc
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SHIMADA Kazuyuki
Department of Medicine, Jichi Medical University
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MORISHITA Yoshihisa
Department of Hematology and Oncology JA Aichi Konan Kosei Hospital
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KOHNO Akio
Department of Hematology and Oncology JA Aichi Konan Kosei Hospital
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NARIMATSU Hiroto
Department of Hematology and Oncology, Nagoya University Graduate School of Medicine
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Ozeki Kazutaka
愛知県厚生連昭和病院
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Ozeki Kazutaka
Division Of Hematology And Oncology Ja Aichi Showa Hospital
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Ozeki Kazutaka
Molecular Medicine Nagoya University Graduate School Of Medicine
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Kohno Akio
愛知県厚生連昭和病院
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Kohno Akio
Division Of Hematology And Oncology Ja Aichi Showa Hospital
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Kohno A
Nagoya Univ. School Of Medicine Nagoya Jpn
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Kamiya Yoshikazu
Department Of Hematology Meitetsu Hospital
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Kato Y
Meiji Univ. Kanagawa Jpn
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Kunitomi Akane
名鉄病院 血液内科
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Matsuno Yoshihiro
Department Of Chemotherapy Tokyo Metropolitan Cancer And Infectious Diseases Center Komagome Hospita
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SAITO Shigeki
Department of Hematology and Oncology, JA Aichi Showa Hospital
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Shimada Kazuyuki
Department Of Hematology And Oncology Ja Aichi Showa Hospital
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Kohno Akio
First Department Of Internal Medicine Nagoya University School Of Medicine
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Kato Yukio
Department Of Applied Biological Science Tokyo University Of Science
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Morishima Yasuo
Department Of Hematology And Chemotherapy
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Narimatsu Hiroto
Department Of Hematology And Oncology Ja Aichi Showa Hospital
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Moriuchi Yukiyoshi
Nagasaki Cml Study Group Nagasaki Jpn
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Shimada Kazuyuki
Department Of Anatomy School Of Medicine Showa University
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Saito Shigeki
Department Of Hematology And Oncology Ja Aichi Showa Hospital
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Kato Yukio
Department Of Hematology And Oncology Ja Aichi Showa Hospital
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Morishima Yasuo
Department Of Pathology And Oncology Institute Of Medical Science University Of Tokyo
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