Single-chain tissue-type plasminogen activator is a substrate of mouse glandular kallikrein 24
スポンサーリンク
概要
- 論文の詳細を見る
Leydig cells of the adult mouse testis express at a detectable level three distinct glandular (tissue) kallikrein genes: mKlk21, mKlk24, and mKlk27. Recently, the proteins encoded by these genes were characterized using active recombinant proteases, but their roles in the mouse testis remained to be determined. The present study showed that among the proteases, mK24 markedly enhanced the activity of human recombinant single-chain tissue-type plasminogen activator when the two were incubated together. This activation was found to be due to proteolytic conversion of the single-chain enzyme to a two-chain form. The expression of tissue-type plasminogen activator in interstitial Leydig cells was demonstrated by RT-PCR and immunohistochemical analyses. The primary culture medium of adult male testicular Leydig cells contained immunoreactive substances recognized by anti-mK24 antibodies. In addition, the same medium was capable of converting the single-chain plasminogen activator to the two-chain protein. These results suggest that mK24 may play a role in the degradation of extracellular matrix proteins in the interstitial area surrounding the Leydig cells of the adult mouse testis, due not only to its own activity, but also to that of plasmin produced by the single-chain tissue-type plasminogen activator-converting activity of mK24.
- 社団法人日本動物学会の論文
- 2005-10-25
著者
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MORIYAMA Akihiko
Division of Biomolecular Science, Institute of Natural Sciences, Nagoya City University
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高橋 孝行
北海道大学大学院先端生命科学研究院
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Takahashi T
Biological Laboratory Nishikyushu University
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高橋 孝行
Dep. Of Biophysics And Biochemistry Graduate School Of Sci. Univ. Of Tokyo
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Matsui Hitoshi
Division of Biological Sciences, Graduate School of Science, Hokkaido University
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Takahashi Takayuki
Division of Biological Sciences, Graduate School of Science, Hokkaido University
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Moriyama Akihiko
Division Of Biomolecular Science Institute Of Natural Sciences Nagoya City University
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Takahashi Takayuki
Division Of Biological Sciences Graduate School Of Science Hokkaido University
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Takano Naoharu
Division of Biological Sciences, Graduate School of Science, Hokkaido University
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Takano Naoharu
Division Of Biological Sciences Graduate School Of Science Hokkaido University
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Takano Naoharu
The Division Of Biological Sciences Graduate School Of Science
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Takahashi Toshiyuki
Department Of Biology Keio University
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Takahashi Takayuki
Division Of Biological Science Graduate School Of Science Hokkaido University
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Takano N
Division Of Biological Sciences Graduate School Of Science Hokkaido University
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Matsui Hitoshi
Division Of Biological Sciences Graduate School Of Science Hokkaido University
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Takahashi Toshiyuki
Department Of Biological Science Graduate School Of Science Hiroshima University
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Takahashi Takayuki
Department Of Biophysics And Biochemistry Graduate School Of Science University Of Tokyo
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