Characterization of mouse tissue kallikrein 5
スポンサーリンク
概要
- 論文の詳細を見る
Mouse tissue kallikreins (Klks) are members of a large, multigene family consisting of 37 genes, 26 of which can code for functional proteins. Mouse tissue kallikrein 5 (Klk5) has long been thought to be one of these functional genes, but the gene product, mK5, has not been isolated and characterized. In the present study, we prepared active recombinant mK5 using an Escherichia coli expression system, followed by column chromatography. We then determined the biochemical and enzymatic properties of purified mK5. mK5 had trypsin-like activity for Arg at the P1 position, and its activity was inhibited by typical serine protease inhibitors. mK5 degraded gelatin, fibronectin, collagen type IV, high-molecular-weight kininogen, and insulin-like growth factor binding protein-3. Our data suggest that mK5 may be implicated in the process of extracellular matrix remodeling.
- Zoological Society of Japanの論文
- 2006-11-25
著者
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Takahashi Sumio
岡山大学 理学部生物学科
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Takahashi Sumio
Department Of Applied Physics The National Defense Academy
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高橋 孝行
北海道大学大学院先端生命科学研究院
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Hirata Kensaku
Department of Biology, Faculty of Science, Okayama University
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Takahashi Sumio
The Graduate School Of Natural Sci. And Technol. Okayama Univ. Jpn
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Takahashi T
Biological Laboratory Nishikyushu University
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Rajapakse Sanath
Hokkaido Univ. Sapporo Jpn
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高橋 孝行
Dep. Of Biophysics And Biochemistry Graduate School Of Sci. Univ. Of Tokyo
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OGIWARA Katsueki
Laboratory of Molecular and cellular Interactions, Faculty of Advanced Life Science, Hokkaido Univer
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TAKAHASHI Takayuki
Laboratory of Molecular and cellular Interactions, Faculty of Advanced Life Science, Hokkaido Univer
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RAJAPAKSE Sanath
Laboratory of Molecular and Cellular Interactions, Faculty of Advanced Life Science, Hokkaido Univer
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YAMANO Noriko
Department of Biology, Faculty of Science, Okayama University
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KIMURA Atsushi
Laboratory of Molecular and Cellular Interactions, Faculty of Advanced Life Science, Hokkaido Univer
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Takahashi Sumio
Department Of Applied Physics National Defense Academy
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Takahashi Sumio
Department Of Biology Faculty Of Science Okayama University
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Kimura Atsushi
Laboratory Of Molecular And Cellular Interactions Faculty Of Advanced Life Science Hokkaido Universi
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Yamano Noriko
Department Of Biology Faculty Of Science Okayama University
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Takeuchi Sakae
Department Of Biology Graduate School Of Natural Science And Technology Okayama University
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Hirata Kensaku
Department Of Biology Faculty Of Science Okayama University
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Takahashi Toshiyuki
Department Of Biology Keio University
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Takahashi S
Department Of Biology Faculty Of Science Okayama University Tsushima
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Takeuchi S
Department Of Biology Faculty Of Science Okayama University Tsushima
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Ogiwara Katsueki
Laboratory Of Molecular And Cellular Interactions Faculty Of Advanced Life Science Hokkaido Universi
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Takeuchi Sakae
Graduate School Of Natural Science And Technology Okayama University
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Takahashi Takayuki
Laboratory Of Molecular And Cellular Interactions Faculty Of Advanced Life Science Hokkaido Universi
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Takahashi Toshiyuki
Department Of Biological Science Graduate School Of Science Hiroshima University
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Takahashi Takayuki
Department Of Biophysics And Biochemistry Graduate School Of Science University Of Tokyo
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Taniuchi Shusuke
Graduate School Of Natural Science And Technology Okayama University
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