Runx3 Expression and Its Roles in Mouse Endometrial Cells
スポンサーリンク
概要
- 論文の詳細を見る
Runx3 is a transcription factor that belongs to the Runx family. We studied the localization of Runx3 mRNA in the mouse uterus, and its function in the mouse endometrium using Runx3 knockout (Runx3–/–) mice. Runx3 mRNA was detected in the endometrial luminal epithelial cells, glandular epithelial cells and stromal cells below the epithelial cell layer on the luminal side. The uteri of Runx3–/– mice were smaller than those of wt mice. The endometrial layer and uterine glands of Runx3–/– mice were less developed than those of wild-type mice, and the endometrial stromal layer was thinner. Transforming growth factor β1 and β3 (TGFβ1 and β3) mRNA levels in endometrial stromal cells of Runx3–/– mice were low compared with those of wild-type mice. Estradiol-17β (E2) increased Tgfb2 mRNA levels in endometrial stromal cells of Runx3–/– mice, but not in those of wild-type mice. E2 increased epidermal growth factor (EGF) mRNA levels in endometrial stromal cells of wild-type mice, but did not increase those of Runx3–/– mice. The diminished Tgfb1 and Tgfb3 mRNA expressions may lead to the reduced proliferation of endometrial stromal cells. Alterations of E2-associated expressions of Tgfb2 and Egf mRNA in endometrial stromal cells of Runx3–/– mice may be associated with suppression of E2-dependent endometrial epithelial cell proliferation in Runx3–/– mice. Thus, Runx3 is likely to be a regulatory factor responsible for endometrial growth.
著者
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Takahashi Sumio
岡山大学 理学部生物学科
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Takeuchi Sakae
Graduate School Of Natural Science And Technology Okayama University
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Takahashi Sumio
Graduate School Of Natural Science And Technology Okayama University
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Taniuchi Shusuke
Graduate School Of Natural Science And Technology Okayama University
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TSUCHIYA Yukiko
Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
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SAITO Yuka
Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
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SAKUMA Atsuko
Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
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MAEKAWA Tetsuya
Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
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FUKAMACHI Hiroshi
Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo 113-8519, Japan
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SAITO Yuka
Graduate School of Natural Science and Technology, Okayama University
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FUKAMACHI Hiroshi
Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University
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SAKUMA Atsuko
Graduate School of Natural Science and Technology, Okayama University
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TAKAHASHI Sumio
Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan
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