Interleukin-18(IL-18) mRNA Expression and Localization of IL-18 mRNA-Expressing Cells in the Mouse Uterus(Endocrinology)
スポンサーリンク
概要
- 論文の詳細を見る
Interleukin-18 (IL-18) belongs to the interleukin-1 family and was identified as an interferon-γ inducing factor. We investigated IL-18 mRNA-expressing cells in the mouse uterus. By Rnase protection assay, IL-18 mRNA and α subunit of IL-18 receptor mRNA were detected in the uterus. In the uterus, IL-18 mRNA levels increased during sexual maturation. In situ hybridization analysis demonstrated IL-18 mRNA-expressing cells in the mouse uterus of different ages. At 21 days of age, IL-18 mRNA-expressing cells were detected in the luminal epithelial cells and stromal cells although the IL-18 mRNA signal was weak. At 42 days of age, IL-18 mRNA signal was mainly detected in the stromal cells located near the myometrium, and in some of the luminal and glandular epithelial cells. In the uterus of 63-day-old adult mice, a strong hybridization signal for IL-18 mRNA was detected at estrus, but was weak at diestrus. IL-18 mRNA was mainly detected in the glandular epithelial cells and stromal cells. The effect of estradiol17β (E_2) on IL-18 mRNA-expressing cells in the uterus was examined in ovariectomized mice. In oil-treated mice IL-i8 mRNA signal was localized in luminal epithelial cells and stromal cells, while in E_2-treated mice lL-18 mRNA signal was localized in stromal cells alone. These results suggest that the mouse uterus has an IL-18 system, and lL-18 exerts a physiological role within the uterus in a paracrine manner, and that IL-18 gene expression is regulated by estrogen.
- 社団法人日本動物学会の論文
- 2005-09-25
著者
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Takahashi Sumio
岡山大学 理学部生物学科
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Otsuki Mariko
Department of Biology, Faculty of Science, Okayama University
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Murakami Yousuke
Department of Biology, Faculty of Science, Okayama University
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Takahashi Sumio
The Graduate School Of Natural Sci. And Technol. Okayama Univ. Jpn
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KUSUMOTO Kenji
Department of Plastic and Reconstructive Surgery, Kansai Medical University
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Kanayama Munetoshi
Tsushima Facility, Advanced Science Research Center, Okayama University
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Takeuchi Sakae
Tsushima Facility, Advanced Science Research Center, Okayama University
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Takahashi Sumio
Tsushima Facility, Advanced Science Research Center, Okayama University
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Takahashi Sumio
Department Of Biology Faculty Of Science Okayama University
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Takeuchi Sakae
Department Of Biology Graduate School Of Natural Science And Technology Okayama University
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Murakami Y
Department Of Biology Graduate School Of Natural Science And Technology Okayama University
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Kusumoto Kenji
Department Of Biology Graduate School Of Natural Science And Technology Okayama University
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Takahashi S
Department Of Biology Faculty Of Science Okayama University Tsushima
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Otsuki Mariko
Department Of Biology Graduate School Of Natural Science And Technology Okayama University
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Takeuchi S
Department Of Biology Faculty Of Science Okayama University Tsushima
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Takeuchi Sakae
Graduate School Of Natural Science And Technology Okayama University
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Taniuchi Shusuke
Graduate School Of Natural Science And Technology Okayama University
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Kanayama M
Tsushima Facility Advanced Science Research Center Okayama University
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Murakami Yousuke
Department of Biology, Factory of Science, Okayama University
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Kusumoto Kenji
Department of Anatomy, School of Medicine, Jichi Medical University
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