Expression of Interleukin-18 Receptor mRNA in the Mouse Endometrium
スポンサーリンク
概要
- 論文の詳細を見る
Interleukin-18 (IL-18) is a proinflammatory cytokine involved in chronic inflammation, autoimmune diseases, and a variety of cancers, and is expressed in mouse uteri. Our previous study suggested that IL-18 acts as a paracrine factor, regulating endometrial function. To elucidate the physiological roles of IL-18 in the mouse endometrium, the expression of the IL-18 receptor (IL-18R) α subunit was analyzed. IL-18R α mRNA was expressed in several mouse organs in addition to the endometrium. In situ hybridization analysis using a biotin-labeled mouse IL-18Rα riboprobe demonstrated that IL-18Rα mRNA expression was detected in glandular epithelial cells, stromal cells around uterine glands, and myometrial cells in the mouse uterus, suggesting that these cells are targets for IL-18. The uterine IL-18Rα mRNA expression level changed with the estrous cycle. The uterine IL-18Rα mRNA levels of estrous mice were higher than those of diestrous mice. In addition, the IL-18Rα mRNA levels in uteri at 3 and 14 days after ovariectomy were higher than those at diestrus and decreased following treatment with estradiol-17β or progesterone. These findings suggest that IL-18Rα gene expression is regulated by estrogen and progesterone and that the uterine IL-18 system is involved in the regulation of uterine functions in a paracrine manner.
- 日本繁殖生物学会の論文
著者
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Takahashi Sumio
Department Of Applied Physics The National Defense Academy
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Otsuki Mariko
Department of Biology, Faculty of Science, Okayama University
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Murakami Yousuke
Department of Biology, Faculty of Science, Okayama University
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Takeuchi Sakae
Department of Biology, Faculty of Science, Okayama University
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KUSUMOTO Kenji
Department of Plastic and Reconstructive Surgery, Kansai Medical University
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Kanayama Munetoshi
Tsushima Facility, Advanced Science Research Center, Okayama University
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Takahashi Sumio
Department Of Applied Physics National Defense Academy
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Takeuchi Sakae
Department Of Biology Graduate School Of Natural Science And Technology Okayama University
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Murakami Y
Department Of Biology Graduate School Of Natural Science And Technology Okayama University
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Kusumoto Kenji
Department Of Biology Graduate School Of Natural Science And Technology Okayama University
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Otsuki Mariko
Department Of Biology Graduate School Of Natural Science And Technology Okayama University
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Takeuchi Sakae
Department Of Biology Faculty Of Science Okayama University
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Murakami Yousuke
Department of Biology, Factory of Science, Okayama University
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Kusumoto Kenji
Department of Anatomy, School of Medicine, Jichi Medical University
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TAKEUCHI Sakae
Department of Biology, Graduate School of Natural Science and Technology, Okayama University
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TAKAHASHI Sumio
Department of Biology, Graduate School of Natural Science and Technology, Okayama University
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