Experimental Manipulation of Pituitary Hemorrhage Induced by Intraperitoneal Injection of a Hypertonic Solution in Mice

概要

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Acute and intense hemorrhage into the anterior pituitary in mice can be induced by the intraperitoneal injection of a 35% glucose solution at a dose of 0.03 ml/g bw. Experimental manipulations that stimulate or inhibit this pituitary hemorrhage were investigated. A rise in plasma osmolality paralleled a rise in the incidence of pituitary bleeding. Water deprivation facilitated the incidence of pituitary hemorrhage at a low dose of a 35% glucose solution (0.015 ml/g bw) that was without effect in control mice. In contrast, the incidence of the pituitary hemorrhage reduced in nursing dams. Enhancement of the pituitary hemorrhage was obtained by the pretreatment with agents including norepinephrine , epinephrine , bromocriptine and thiamazole despite a low dose of a glucose solution applied . On the other hand, pituitary hemorrhage was evidently suppressed by treatment with agents including haloperidol, sulpiride, metoclopramide, pentobarbital and ether inhalation prior to the injection of a high dose of the glucose solution. These results suggested a stimulative effect of dopamine on induction of the pituitary hemorrhage.
社団法人日本動物学会の論文
1994-02-15