A Morphometric Study on Pituitary Pars Intermedia Cells of Male Mice Fed a Liquid Diet Supplemented with Urea(Endocrinology)

概要

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An electron microscopic and morphometric study on pars intermedia (PI) cells of the pituitary was undertaken in male mice given either a liquid diet consisting of 3% powdered milk in a 5% glucose solution or the identical liquid diet supplemented with 1% urea for 10 days. Three parameters representing the secretory activity of PI cells were examined. The percent area of the cytoplasm occupied by the rough endoplasmic reticulum (an index of protein synthesis) increased to 124% and 172% of the control value in mice maintained on the liquid diet alone and on the liquid diet containing 1% urea, respectively; the numerical density of immature Golgi granules (an index of granule formation) also increased to 143% and 185% of the control value in those given the liquid giet alone and the liquid diet supplemented with 1% urea, respectively. In contrast, the numerical density of secretory granules (an index of granule storage) decreased to 74% and 62% of the control value in animals fed the liquid diet alone and the liquid diet supplemented with 1% urea, respectively. These results indicate that the balance between synthesis and release of PI hormones is in equilibrium at a higher level in mice fed the liquid diet with urea than in animals given the liquid diet without urea.
社団法人日本動物学会の論文
1991-10-15