Effects of Neonatal Administration of Monosodium Glutamate on the Pars Intermedia of the Mouse Pituitary : A Morphometric Study(COMMUNICATION)(Endocrinology)
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概要
- 論文の詳細を見る
Effects of neonatal administration of monosodium glutamate (MSG) on Lee-index, endocrine organ weights and the secretory activity of pars intermedia cells in quantitative fine structures were investigated in mice at 1, 5 and 10 months of age. Mice treated with MSG (4 mg/g body weight) from 5 to 10 days of neonatal life showed obesity and stunted growth when they grew adult. Endocrine organs like the pituitary, thyroids, adrenals and testes decreased in weight except for the adrenal gland at 1 month of age. The pars intermedia cells of the pituitary showed a cytological sign of hypersecretion in MSG-treated animals at 1 and 5 months of age. A significant increase both in the percent area of r-ER and the number of immature Golgi granules and a concomitant decrease in the numerical density of secretory granules were observed in the pars intermedia cells. However, these morphological changes were no more detected in MSG-treated mice at 10 months of age. These results suggest that MSG-induced lesions of the hypothalamic arcuate nucleus attenuated the dopaminergic inhibitory influence on the pars intermedia for, at least, about 5 months after the treatment.
- 社団法人日本動物学会の論文
- 1985-06-15
著者
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Kondo J
Kyoto Univ. Kyoto
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Kondo Junichi
Department Of Material Chemistry Graduate School Of Engineering Kyoto University
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Kobayashi Yasuo
Department Of Applied Biochemistry Hiroshima University
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Kobayashi Yasuo
Department Of Anesthesia Asahikawa City Hospital
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Kondo Junichi
Department of Biology, Faculty of Science, Okayama University
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