エストロゲンはマウス子宮におけるインターロイキン-18mRNA発現を阻害する
スポンサーリンク
概要
- 論文の詳細を見る
Interleukin-18 (IL-18) is a proinflammatory cytokine expressed in female reproductive organs in humans, rats and mice. The physiological roles of uterine IL-18 andthe regulatory mechanisms of IL-18 gene expression are unclear. The present study aimed to clarify the effects of estradiol-17β (E2) and progesterone (P4) on IL-18 mRNA expression in the mouse uterus. Distribution and expression levels of IL-18 mRNA were studied using an RNase protection assay. Expression of IL-18 mRNA was observed in all organs studied, including testes, ovaries and uteri. The uterine IL-18 mRNA level of estrous mice was higher than that of diestrous mice. E2 treatment (1, 5, 25 or 250 ng/mouse) decreased uterine IL-18 mRNA levels in ovariectomized mice dose-dependently. E2 treatment acutely decreased IL-18 mRNA levels 3 h after injection, but these levels returned to the initial level after 48 h. P4 treatment (1 mg/mouse) decreased uterine IL-18 mRNA levels after 12 h, but levels returned to the initial level after 48 h. Both uterine IL-18 and IL-18Rα mRNAs were detected in cultured endometrial epithelial and stromal cells. These results suggest that uterine IL-18 expression is reduced by sex steroid hormones and that IL-18 acts on endometrial cells in a paracrine or autocrine manner.
- 日本繁殖生物学会の論文
著者
-
Takahashi Sumio
Department Of Applied Physics The National Defense Academy
-
Murakami Yousuke
Department of Biology, Faculty of Science, Okayama University
-
Takeuchi Sakae
Department of Biology, Faculty of Science, Okayama University
-
村上 要介
Department of Biology, Faculty of Science, Okayama University
-
大月 真理子
Department of Biology, Faculty of Science, Okayama University
-
楠本 憲司
Department of Biology, Faculty of Science, Okayama University
-
Takahashi Sumio
Department Of Applied Physics National Defense Academy
-
Takeuchi Sakae
Department Of Biology Graduate School Of Natural Science And Technology Okayama University
-
Kusumoto Kenji
Department Of Biology Graduate School Of Natural Science And Technology Okayama University
-
Otsuki Mariko
Department Of Biology Graduate School Of Natural Science And Technology Okayama University
-
Takeuchi Sakae
Department Of Biology Faculty Of Science Okayama University
関連論文
- Alternative Leader-Exon Usage in Mouse IGF-I mRNA Variants: Class 1 and Class 2 IGF-I mRNAs
- REGULATION OF mRNA EXPRESSIONS OF GROWTH FACTORS AND STEROID HORMONE RECEPTORS IN CULTURED MOUSE UTERINE CELLS(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- TRANSFORMING GROWTH FACTOR α EXPRESSION IN THE MOUSE UTERINE ENDOMETRIUM
- エストロゲンはマウス子宮におけるインターロイキン-18mRNA発現を阻害する
- Transmitting and Receiving Voltage Sensitivity for Piezoelectric Rubber Transducers on a Plate : Ultrasonic Motor, Actuator and Transducer
- Multiple Scattering Effects of Doublet Cavities in Rubber : Underwater Acoustics
- Anisotropy of Sound Speed and Absorption Coefficient of FRP Plate : Ultrasonic Propagation and Field
- Relation between Active Sound Absorption and Mutual Radiation Resistance of an Array of Piston Transducers in Water : Ultrasonic Propagation and Field
- Simultaneous Sensing of Acoustic Wave and Temperature Using a Polarization-Maintaining Fiber : Acoustical Measurements and Instrumentation
- One-Dimensional Constant Beamwidth Transducer : Ultrasonic Transduction
- A Single Fiber Heterodyne Optical Fiber Hydrophone : Acoustical Measurements and Instrumentation
- A Single Fiber Hydrophone of Interference Type Using Polarization-Maintaining Fiber : Ultrasonic Transduction
- Endfire Radiation of Acoustic Helical Antennas : Ultrasonic Transduction
- Both PPARγ and C/EBPα are Sufficient to Induce Transdifferentiation of Goat Fetal Myoblasts into Adipocytes
- Characterization of mouse tissue kallikrein 5
- EXPRESSION OF INTERLEUKIN-18 RECEPTOR mRNA IN THE DECIDUALIZATION OF MOUSE UTERI(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- REGULATORY MECHANISM OF PROLIFERATION OF PROLACTIN-SECRETING CELLS IN THE MOUSE PITUITARY(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- EXPRESSION OF ESTROGEN RECEPTOR ISOFORMS IN THE PITUITARY GLANDS OF DIABETIC MICE(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- PHYSIOLOGICAL ROLE OF INTERLEUKIN-18 IN THE MOUSE PITUITARY(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- EFFECT OF STEROID HORMONES, GROWTH FACTORS AND CYTOKINES ON THE EXPRESSION OF MATRIX METALLOPROTEINASE mRNAS IN THE MOUSE UTERUS
- SEX STEROID HORMONES REGULATE TRANSFORMING GROWTH FACTOR-α mRNA LEVELS IN MOUSE UTERINE CELLS
- THE ROLE OF INTERLEUKIN-18 FOR APOPTOSIS IN THE MOUSE TESTIS
- EXPRESSION OF ESTROGEN RECEPTOR mRNAs IN THE MOUSE PITUITARY GLANDS
- Interleukin-18(IL-18) mRNA Expression and Localization of IL-18 mRNA-Expressing Cells in the Mouse Uterus(Endocrinology)
- EXPRESSION OF THE GROWTH HORMONE GENE IN PERIPHERAL TISSUES OF THE CHICKEN(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- EXPRESSION OF INTERLEUKIN-18 mRNA IN THE MOUSE PITUITARY(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- ANALYSIS OF EXPRESSION AND EFFECTS OF INTERLEUKIN-18 IN THE MOUSE UTERUS(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- MATRIX METALLOPROTEINASE mRNA EXPRESSION IN THE MOUSE UTERUS(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- Polarimetric Optical Fiber Hydrophone Using Birefringence of LiNbO_3
- Optical Detection of Acoustic Pressure Using Birefringence of (Pb, La)(Zr, Ti)O_3 Ceramics
- Forward Scattered Sound Field by Parallel Cylinders : Ultrasonic Propagation and Field
- Pr^-Doped Superfluorescent Fluoride Fiber Laser
- A Defect-Induced Absorption Loss in ZrF_4-Based Fluoride Glasses
- New Process for Fluoride Glass Preform Fabrication Using Chemical Vapor Deposition
- Organometallic Chemical Vapor Deposition of ZrF_4-Based Fluoride Glasses
- Underwater Acoustic Sensor with Fiber Bragg Grating
- Fatigue Test of Piezoelectric Ceramics under High Hydrostatic Pressure : Ultrasonic Transduction
- Fiber-Optic Hydrophone using a Zeeman Laser : Underwater Acoustics
- Fiber Bragg Grating Vibration Sensor Using Incoherent Light
- Detection of Ultrasonic Mechanical Vibration of a Solid Using Fiber Bragg Grating
- INTERLEUKIN-18 AND ITS RECEPTOR mRNA EXPRESSION IN THE MOUSE TESTIS(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- INSULIN-LIKE GROWTH FACTOR I (IGF-I) GENE EXPRESSION IN MOUSE UTERINE STROMAL CELLS(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- ESTRADIOL-17β STIMULATES THE SYNTHESIS OF INSULIN-LIKE GROWTH FACTOR I (IGF-I) AND THE PROLIFERATION OF UTERINE STROMAL CELLS IN MICE
- The effect of synthetic retinoid, Am80, on T helper cell development and antibody production in murine collagen-induced arthritis
- インスリン様成長因子1はマウス子宮内膜間質細胞のDNA合成を促進する
- Effect of Hypoglycemic Stress on the Pars Intermedia of the Mouse Pituitary Gland : An Ultrastructural Analysis
- Transmission Loss Characteristics of a Fluoride Optical Fiber in the Near-Ultraviolet to Mid-Infrared Wavelength Region
- HEPATOCYTE GROWTH FACTOR AS A LOCAL REGULATOR IN BOVINE ENDOMETRIUM
- Gene Expression and the Physiological Role of Transforming Growth Factor-α in the Mouse Pituitary(Endocrinology)
- Induction of mammotroph development by a combination of epidermal growth factor, insulin, and estradiol-17β in rat pituitary tumor GH3 cells(Endocrinology)
- Myogenic and Adipogenic Properties of Goat Skeletal Muscle Stem Cells
- Improvement of the Sensitivity of a Polarimetric Heterodyne Fiber-Optic Underwater Acoustic Sensor : Ultrasonic Motor, Actuator and Transducer
- Expression of Interleukin-18 Receptor mRNA in the Mouse Endometrium
- Estrogen Inhibits Interleukin-18 mRNA Expression in the Mouse Uterus
- Epidermal Growth Factor and Transforming Growth Factor-α Stimulate the Proliferation of Mouse Uterine Stromal Cells(Endocrinology)
- Expression of Interleukin-18 Receptor mRNA in the Mouse Endometrium
- INTERLEUKIN-18 RECEPTOR α, β GENE EXPRESSION IN THE MURINE ENDOMETRIUM(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- EXPRESSION OF INTERLEUKIN-18 RECEPTOR GENE IN MICE(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- ALTERATION OF IL-18 GENE EXPRESSION IN THE MOUSE UTERUS DURING THE ESTROUS CYCLE(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- ANALYSIS OF GENE EXPRESSION OF INTERLEUKIN-18 IN MOUSE REPRODUCTIVE ORGANS(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- EFFECT OF ESTRADIOL-17β ON GENE EXPRESSION OF INTERLEUKIN-18 IN MOUSE REPRODUCTIVE ORGANS
- INTERLEUKIN-18 mRNA-EXPRESSING CELLS IN THE MOUSE UTERUS(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- EXPRESSION OF INTERLEUKIN-18 mRNA IN THE MOUSE PITUITARY AND UTERUS(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- EXPRESSION OF TRANSFORMING GROWTH FACTOR ALPHA IN MALES AND FEMALES DURING POSTNATAL DEVELOPMENT OF THE MOUSE ANTERIOR PITUITARY GLAND(Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Preparation of ZBLAN Fluoride Glass Particles by Chemical Vapor Deposition Process
- Oxygen Doping Effects on Thermal Properties of ZrF_4-BaF_2 Glasses Synthesized by Plasma-Enhanced Chemical Vapor Deposition
- Preparation and Properties of ZrF_4-Based Fluoride Glass Films by Plasma-Enhanced Chemical Vapor Deposition
- Satellite Cell Differentiation in Goat Skeletal Muscle Single Fiber Culture
- Myogenic and Adipogenic Properties of Goat Skeletal Muscle Stem Cells
- Spectral Change in Acoustic Pressure and Cavitation Inception
- Insulin-Like Growth Factor-I Stimulated DNA Replication in Mouse Endometrial Stromal Cells
- GROWTH HORMONE AND INSULIN-LIKE GROWTH FACTOR-I REGULATE POMC mRNA LEVEL IN AtT-20 CELLS(Endocrinology & Genetics,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- GENE EXPRESSION OF GH-R AND IGF-IR IN AtT-20 CORTICOTROPIC CELLS(Biochemistry & Endocrinology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- REGULATION OF PROOPIOMELANOCORTIN GENE EXPRESSION IN CORTICOTROPIC TUMOR AtT-20 CELLS
- Epidermal Growth Factor Stimulates Proliferation of Mouse Uterine Epithelial Cells in Primary Culture(Endocrinology)
- Insulin-Like Growth Factor-I and Its Receptor in Mouse Pituitary Glands
- INSULIN-LIKE GROWTH FACTOR-I AND EPIDERMAL GROWTH FACTOR STIMULATE THE PROLIFERATION OF THE MOUSE UTERINE EPITHELIAL CELLS
- EPIDERMAL GROWTH FACTOR AND ITS RECEPTORS IN THE MOUSE PITUITARY GLANDS
- ACTIVATION OF RECEPTORS FOR EPIDERMAL GROWTH FACTOR(EGF) IS REQUIRED FOR ESTROGEN-INDUCED PROLIFERATION OF MOUSE PITUITARY CELLS
- Proliferation of Pituitary Cells in Streptozotocin-induced Diabetic Mice : Effect of Insulin and Estrogen
- Experimental Manipulation of Pituitary Hemorrhage Induced by Intraperitoneal Injection of a Hypertonic Solution in Mice
- IDENTIFICATION OF A NOVEL GROWTH HORMONE (GH) ISOFORM EXPRESSED IN THE DEVELOPING CHICKEN EYE
- STRUCTURE AND EXPRESSION OF THE CHICKEN PRO - OPIOMELANOCORTIN (POMC) GENE
- REGULATION OF EXPRESSION OF GH RECEPTOR mRNA IN THE MOUSE ANTERIOR PITUITARY GLAND(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- Augmentation of Prolactin Release by α-Melanocyte Stimulating Hormone Is Possibly Mediated by Melanocortin 3-Receptors in the Mouse Anterior Pituitary Cells
- Underwater Acoustic Sensor Using Optical Fiber Bragg Grating as Detecting Element
- Measurement of Acoustic Nonlinearity Parameter of Liquids by the Observation of Waveforms
- Measurement of Cavitation Noise and Bubble Oscillation using Acoustooptic Detection Scheme
- Heterogeneity and Development of Somatotrophs and Mammotrophs in the Rat
- A Single Fiber Hydrophone of Non-Interference Type Using Polarization-Maintaining Fiber : Ultrasonic Transduction
- An Optical Fiber Hydrophone Using Polarization-Maintaining Fiber : Ultrasonic Transduction
- Intrapituitary Regulatory System of Proliferation of Mammotrophs in the Pituitary Gland
- Comparison of Optical Fiber Hydrophones : Ultrasonic Imaging
- EFFECT OF TRANSFORMING GROWTH FACTOR-BETA ON THE PROLIFERATION OF MOUSE UTERINE ENDOTHELIAL CELLS(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- DYNAMICS OF MESSENGER RNA ENCODING GROWTH FACTORS IN THE ANTERIOR PITUITARY DURING THE RAT ESTROUS CYCLE(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- FUNCTIONAL CHARACTERIZATION OF MOUSE MELANOCORTIN 3 RECEPTOR GENE PROMOTER(Endocrinology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- REGULATION OF MC3-R mRNA IN THE MOUSE PITUITARY GLAND(Endocrinology & Genetics,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- EFFECT OF DOPAMINE ON EXPRESSION OF TRANSFORMING GROWTH FACTOR-α, PROLACTIN AND GROWTH HORMONE mRNAs IN THE MOUSE ANTERIOR PITUITARY(Endocrinology & Genetics,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- EXPRESSION OF TRANSFORMING GROWTH FACTOR-β-mRNA IN THE MOUSE UTERINE STROMAL CELLS(Endocrinology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Establishment of bipotent progenitor cell clone from rat skeletal muscle