Gelatinase A and membrane-type matrix metalloproteinases 1 and 2 are responsible for follicle rupture during ovulation in the medaka
スポンサーリンク
概要
- 論文の詳細を見る
Identification of the hydrolytic enzymes involved in follicle rupture during vertebrate ovulation remains a central challenge for research in reproductive biology. Here, we report a previously uncharacterized approach to this problem by using an in vitro ovulation system in the medaka, Oryzias latipes, which is a small freshwater teleost. We found that follicle rupture in the medaka ovary involves the cooperation of at least three matrix metalloproteinases (MMPs), together with the tissue inhibitor of metalloproteinase-2b protein. We determined the discrete roles of each of these proteins during follicle rupture. Our results indicated that gelatinase A induces the hydrolysis of type IV collagen constituting the basement membrane, membrane-type 2 MMP degrades type I collagen present in the theca cell layer, and MT1-MMP and the tissue inhibitor of metalloproteinase-2b are involved in the production and regulation of gelatinase A. These findings will help clarify the mechanism of follicle wall degradation during ovulation in mammalian species.
- The National Academy of Sciences of the United States of Americaの論文
- 2005-06-14
著者
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高橋 孝行
北海道大学大学院先端生命科学研究院
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Takahashi T
Biological Laboratory Nishikyushu University
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高橋 孝行
Dep. Of Biophysics And Biochemistry Graduate School Of Sci. Univ. Of Tokyo
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Takahashi Takayuki
Division Of Biological Sciences Graduate School Of Science Hokkaido University
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Takano Naoharu
Division of Biological Sciences, Graduate School of Science, Hokkaido University
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Takano Naoharu
Division Of Biological Sciences Graduate School Of Science Hokkaido University
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Takahashi Toshiyuki
Department Of Biology Keio University
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Takano N
Division Of Biological Sciences Graduate School Of Science Hokkaido University
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Takahashi Toshiyuki
Department Of Biological Science Graduate School Of Science Hiroshima University
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Takahashi Takayuki
Department Of Biophysics And Biochemistry Graduate School Of Science University Of Tokyo
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