Spinal Granulocytic Sarcoma Manifesting as Radiculopathy in a Nonleukemic Patient
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概要
- 論文の詳細を見る
A 26-year-old nonleukemic woman presented with lumbosacral granulocytic sarcoma manifesting as progressive low back pain and numbness of her left lower leg persisting for 3 months. Physical examination revealed hypesthesia within the left Si area of the sensory dermatome, decreased Achilles tendon reflex in the left lower extremity, and walking impairment due to severe pain in her left hip and leg. Magnetic resonance imaging confirmed an extradural mass in the spinal canal at the L5-S2 levels with invasion to the pelvis from the left sacral foramen. Positron emission tomography with [^<18>F] fluorodeoxyglucose (FDG-PET) showed hyperaccumulation indicating malignant tumor. Baseline laboratory data were normal. Decompressive laminectomy and tumor removal were performed. Histological examination identified granulocytic sarcoma. Bone marrow involvement was absent. She underwent adjuvant chemotherapy and radiotherapy, resulting in reduced residual lesion and neurological improvement. Immediate diagnosis and adequate systematic treatment are recommended for spinal granulocytic sarcoma in nonleukemic patients to prevent or delay progression to leukemia. The importance of immunohistochemical staining in the differential diagnosis from other types of spinal tumor, and the efficacy of FDG-PET for evaluation of the treatment are also emphasized.
- 社団法人 日本脳神経外科学会の論文
- 2008-03-15
著者
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SHIMIZU Hiroaki
Department of Neurosurgery, Tohoku University Graduate School of Medicine
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TOMINAGA Teiji
Department of Neurosurgery, Tohoku University Graduate School of Medicine
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KUMABE Toshihiro
Department of Neurosurgery, Tohoku University Graduate School of Medicine
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KANAMORI Masayuki
Department of Neurosurgery, Tohoku University Graduate School of Medicine
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Takahashi Toshiyuki
Department of Cardiology, JR Tokyo General Hospital
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INOUE TOMOO
Department of Surgical Oncology, Osaka University, Medical School
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WATANABE MIKA
Department of Anatomic Pathology, Tohoku University School of Medicine
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Watanabe Mika
Pathological Division Tohoku University Hospital
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Watanabe Mika
Department Of Anatomic Pathology Tohoku University School Of Medicine
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Inoue Tomoo
Department Of Neurosurgery Aomori Prefectural Central Hospital
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Inoue Tomoo
Departments Of Neurosurgery Tohoku University Graduate School Of Medicine
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Takahashi Toshiyuki
Department Of Neurosurgery Kohnan Hospital
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Shimizu Hiroaki
Department Of Neurosurgery Kohnan Hospital
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Shimizu Hiroaki
Department Of Neurosurgery Tohoku University School Of Medicine
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Kumabe Toshihiro
Department Of Neurosurgery Tohoku University Graduate School Of Medicine
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Kanamori Masayuki
Department Of Neurosurgery Tohoku University Graduate School Of Medicine
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Shimizu Hiroaki
Department Of Electrical And Computer Engineering Nagoya Institute Of Technology
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Shimizu Hiroaki
Departments Of Neurosurgery
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Tominaga Teiji
Department Of Neurosurgery Tohoku University Graduate School Of Medicine
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Tominaga Teiji
Department Of Neurosurgery Tohoku Graduate School Of Medicine
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Tominaga Teiji
Neurosurgery Tohoku University Graduate School Of Medicine
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Takahashi Toshiyuki
Department Of Biology Keio University
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Takahashi Toshiyuki
Department Of Biological Science Graduate School Of Science Hiroshima University
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Takahashi Toshiyuki
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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SHIMIZU Hiroaki
Department of Applied Chemistry, Faculty of Engineering, Osaka University
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