Use of Paramecium Species in Bioassays for Environmental Risk Management: Determination of IC_<50> Values for Water Pollutants
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概要
- 論文の詳細を見る
Effect of chemical water pollutants on the growth of two Paramecium species (Paramecium caudatum and Paramecium trichium) were examined. The chemicals used as model chemical pollutants include organic solvents, potential carcinogens, mutagens, metabolic modulators, herbicides, insecticides, fungicides, antimicrobials, heavy metals, and heavy metal-containing chemicals. In this study, the IC_<50> values indicating the concentration of substances inhibiting the proliferation of Paramecium cells by 50% were used instead of the LD_<50> value, which indicates the dose of substances killing half the population of organisms, since the former is a more sensitive parameter for assessing the toxicity of substances at lower concentrations. Among 25 chemicals examined, di-(2-ethylhexyl)phthalate, potassium dichromate, 2,4-dichlorophenoxy acetic acid, and paraquat stimulated the growth of paramecia depending on the concentrations used. Dimethyl sulfoxide and formaldehyde were shown to be inert to paramecia in the range of concentrations (up to 1%, v/v) used here. Other chemicals were shown to inhibit the growth of the paramecia and thus the IC_<50> values for those chemicals were determined. Our data presented here may be a useful reference for assessing the impact of water pollutants on aqueous microecosystems consisting of various microorganisms including protozoa.
- 公益社団法人日本薬学会の論文
- 2003-12-01
著者
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HOSOYA Hiroshi
Department of Biological Science, Graduate School of Science,Hiroshima University
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Tanaka Miho
Department of Cardiology, Nagoya Kyoritsu Hospital
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高橋 孝行
北海道大学大学院先端生命科学研究院
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高橋 孝行
Dep. Of Biophysics And Biochemistry Graduate School Of Sci. Univ. Of Tokyo
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KUNIMOTO Manabu
Environmental Health Sciences Division, National Institute for Environmental Studies
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KAWANO Tomonori
Department of Cardiology and Cardiovascular Surgery, Shinkyo Hospital
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Kunimoto Manabu
Environmental Health Science Division The National Institute For Environmental Studies:(present Addr
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KOSAKA Toshikazu
Department of Biological Science, Faculty of Science, Hiroshima University
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Hosoya H
Graduate School Of Biological Science Hiroshima University
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Hosoya Hiroshi
Department Of Biological Science Faculty Of Science Hiroshima University
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Takahashi Toshiyuki
Department Of Biology Keio University
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Kosaka Toshikazu
Graduate School of Biological Science, Hiroshima University
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Kosaka T
Graduate School Of Biological Science Hiroshima University
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Miyoshi Norikazu
Biological Laboratory, Nishikyushu University
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Kadono Takashi
Department of Biological Science, Graduate School of Science, Hiroshima University
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Takahashi Tadao
Biological Laboratory, Nishikyushu University
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Kosaka Toshikazu
Department Of Biological Science Graduate School Of Science Hiroshima University
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Miyoshi N
National Agricultural Res. Center For Tohoku Region Fukushima‐shi Jpn
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Tanaka Miho
Department Of Biological Chemistry Yamaguchi University
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Tanaka Miho
Department Of Biological Science Graduate School Of Science Hiroshima University:(present Address)in
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Takahashi Tadao
Biological Laboratory Graduate School Of Health And Social Welfare Science Nishikyushu University
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Tanaka Miho
Department Of Applied Chemistry Aichi Institute Of Technology
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Takahashi Takayuki
Department Of Biophysics And Biochemistry Graduate School Of Science University Of Tokyo
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Kawano Tomonori
Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University
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