FUNCTIONAL ANALYSIS OF ATBF1,A MULTIPLE-HOMEODOMAIN ZINC FINGER PROTEIN, USING LUNG CANCER CELL LINE A549

概要

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The transcription factor ATBF1,a multiple-homeodomain zinc finger protein, is highly expressed in various tissues including the developing sensory nervous system, the small intestine and embryonic and adult lung. A histological analysis should give us insight into the function of ATBF1 in the lung. We investigated the localization of ATBF1 in adult mouse lung by in situ hybridization using cRNA and found expression of ATBF1 mRNA in the layer of epithelial cells of bronchioli and bronchi. The A549 cell line, which was derived from a type II pneumocyte tumor, was employed to study the patterns of expression of ATBF1 mRNA under various culture conditions. Although the expression levels of ATBF1 mRNA did not alter during progression of the cell cycle, there was a tendency for A549 cells transfected with ATBF1 cDNA expression vector to accumulate at the G_O/G_1 phase.
名古屋市立大学の論文
2001-09-01