INCORPORATION OF FOREIGN BODY PARTICLES FOLLOWING INJURY IN IMMATURE RAT ARTICULAR CARTILAGE

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The production of particulate wear debris has recently been recognized to result in delayed mechanical failure of joint arthroplastic surgery. In endoprosthtic femoral head replacement, there is also an underlying damage to the acetabular cartilage. To investigate the influence of foreign bodies upon injured cartilage, we studied ultrastructual changes of immature rat patella cartilage following the intraarticular injection of polystyrene latex beads. The articular surfaces of the patellae of 20 and 30 day-old rats were damaged, creating a groove with maximum depth of 100 um. Following the damage, polystyrene beads (240 nm diameter) suspended in saline were injected intraarticularly. Group A received the treatment on day 20,group B on day 30. The patellae in group C were damaged on day 20 and beads applied on day 30. Patella samples were taken an hour after the injection and examined by transmission electron microscope. Erythrocytes were found in the groove which was performed in injury to patella cartilage. Beads were observed entering the damaged cartilage matrix only in group B, and not in the other two groups. A new layer overlying the damaged surface was seen in group C. The prerequisites for incorporation of beads in cartilage are destruction of the collagen network and interstitial fluid flow which depends on compressive loading. Our results indicate that wear debris following endoprostheses can enter damaged cartilage.
名古屋市立大学の論文
2001-02-01

INCORPORATION OF FOREIGN BODY PARTICLES FOLLOWING INJURY IN IMMATURE RAT ARTICULAR CARTILAGE

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