INTER-CELLULAR COMMUNICATIONS IN THE RAT DORSAL ROOT GANGLIA

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The ultrastructural changes in dorsal root ganglia (DRGs) following axotomy have been studied intensively, but no reports have placed emphasis on the cytoplasmic membrane, which plays a significant role in signal transmission through cell-to-cell interaction and uptake of substances into the cytoplasm. Coated pits and gap junctions are special components of the cytoplasmic membrane, the former internalizing substances into the cytoplasm, and the latter allowing intercellular exchange of small molecules. We assessed the chronological alteration of coated pits of nerve cells and distribution of gap junctions of satellite cells following central axotomy. The numbers of coated pits increased at seven days after axotomy compared to control, and then decreased at 14 days after surgery. These changes were significant (p<0.01). Although gap junctions between satellite cells were observed until seven days following axotomy, no gap junctions were observed at 14 days after surgery. The function of the nerve cell is normally maintained through interaction with satellite cells which are connected by gap junctions. At least until seven days after axotomy, satellite cells persist in their support function of the nerve cell as is evident by the existence of gap junctions. Increase of coated pits reflects metabolical changes in the nerve cell. When this neurotrophic intervention fails and the function of the nerve cell is lost, the coated pits decrease and the nerve cell undergoes chromatolysis. In this situation, the synchronization among satellite cells is no longer justified, and gap junctions cannot be observed anymore.
名古屋市立大学の論文
2000-03-31

INTER-CELLULAR COMMUNICATIONS IN THE RAT DORSAL ROOT GANGLIA

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