FUNCTIONAL CHANGES OF RAT SYNOVIAL LINING CELLS WITH POSTNATAL DEVELOPMENT

概要

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Morphological changes and functional maturation in the synovial lining cells of the rat knee joint were examined between day 20 and 30 after birth. Many oblique cells similar to fibroblasts were present in the synovial tissue on day 20. There were also a few undefined cells similar to macrophages. By day 30,two unique cell types could be distinguished : macrophage-like cells (type A cells) and fibroblast-like cells (type B cells). In addition, maturation of the selective phagocytotic uptake by the synovial cells using egg-lecithin coated polystyrene particles (240 nm) was demonstrated. On day 20,fibroblast-like cells were found phagocytizing both non-coated and lecithin-coated particles ; however, macrophage-like cells showed minimal phagocytotic action. By day 30,well-defined type B cells could phagocytize only lecithin-coated particles, and non-coated particles were exclusively phagocytized by type A cells. The particles were also found in the capillary lumina of the 20 day-old rats. Joint cartilage debris and pressure changes during active joint motion might further lead to the maturation of the synovial lining cells. In addition particles found in the capillary lumina indicated that the capillaries were involved in the transfer of particles from the joint cavity.
名古屋市立大学の論文
2000-07-01