GRANULATED FOLLICULO-STELLATE CELLS IN THE NORMAL RAT ANTERIOR RITUITARY GLAND

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Our previous research conducted using rat pituitary gland identified folliculo-stellate 'FS) cells as being agranular and arranged around a follicle, and to contain the S-100 protein and beta adrenergic receptors. Numerous possible functions of the FS cells have proposed other than their putative ACTH-secreting role. However their precise functions remain unknown. Previous research suggested the FS cells represented a degranulated form of a normally granulated, and further that it was a stem cell which eventually transformed into a hormone secreting cell. As a result of such observations and the presence of mitotic figures it was believed that the FS cells could be transformed into granular or chromophilic cells according to the proposed concept of "Cell Renewal System". Moreover, recent advances using freeze-fracture electron microscopy have provided further unique insights on cell surface and gap junctions within the rat or teleost fish pituitary gland, and in cultured rat pituitary cells. It was widely believed that the rat anterior pituitary gland follicles were mostly comprised of agranular FS cells, most previously observed cells were an acidophilic type, with little report attributed to the numerously granulated basophilic type cells. This study reports the discovery of heavily granulated basophilic-type cells, tentatively called "granulated FS cells". The study sought to retrospectively question the "cell renewal system theory, offering further insight relating to the information conducting system of FS cells. Investigations were conducted on granulated FS cells and granulated FS cells of 60-day old rats. The granulated FS cells were separated into two kinds of cells: those containing 100-300 nm in diameter granules concerned as type of basophilic cell, perhaps classical LH-type gonadotrophs, and a further type contained high electron density granule of 300-400 nm in diameter, concerned as a type of acidophilic cell, perhaps classical somatotroph. The findings of the Golgi complex, a property of secretory granules showed the cells to be basophils, and pits of cytoplasmic membrane further indicated elaboration of the synthesizing and secreting activities of the cells. We concluded that granular cells could as previously proposed, transform to granulated cells, additionally performing the role of stem cells for granulated cells, and perform multi -functional role in the cell's information conduction process.
名古屋市立大学の論文
2003-06-28

GRANULATED FOLLICULO-STELLATE CELLS IN THE NORMAL RAT ANTERIOR RITUITARY GLAND

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