THE MECHANISM UNDEREYING HETEROGENEOUS pH IN ISCHEMIC AND REPERFUSED MYOCARDIUM
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概要
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The mechanism reponsible for heterogeneity in tissue pH was investigated in perfused rat hearts subjected to ischemia/reperfusion insult. by correlating the time course of pH changes to the severity of vascular impairment. In 25 per-fused hearts. myocardial pH was monitored by 31 P-NMR spectra. During ischemia. pH. which was 7.1 at the beginning of ischemia. progressively de-creased and reached a steady level of 5.9 (5.9-compartment) after 40 minutes. In addition. another define peak of pH 7.1 (7.1-compartment) became evident after 50 min of ischemia. The 7.1-compartment grew higher with ischemic time and was only observed after 180 min of ischemia. Although reperfusion after 20 min of ischemia recovered pH. ATP, and creatine phosphate. reperfusion after 50 min left two P_i Peaks. the 5.9- and 7.1-compartments: the former gradually decreased with a concomitant increase of the latter. Reperfusion after 180 min of ischemia with various pH levels did not shift the P_i Peak from pH 7.1. suggesting that the perfusate did not reach that compartment. the impaired flow region. High coronary resistance and a heterogeneous staining pattern concomitant with a late appearance of the 7.1 component further supported this hypothesis. Myocardial coenzyme Q_<10> radical. an indicator of the tissue redox state. was also low in those hearts which were reperfused after 50 min of ischemia. Thus. the splitting of the P_i Peak. caused by reperfusion after prolonged ischemia, represents the existence of a no-reflow region.
- 社団法人日本循環器学会の論文
- 1991-05-20
著者
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Nakazawa Hiroe
Department Of Cardiovascular Research Research Institute Of Environmental Medicine Nagoya University
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CHANCE Britton
Department of Biochemistry and Biophysics, University of Pennsylvania
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ICHIMORI KOHJI
Department of Physiology, Tokai University
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NIOKA Shoko
Department of Biochemistry & Biophysics, School of Medicine, University of Pennsylvania
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Chance Britton
Department Of Biochemistry & Biophysics University Of Pennsylvania
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Chance Britton
Department Of Biophysics University Of Pennsylvania
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Nioka Shoko
Department Of Biophysics University Of Pennsylvania
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Ichimori Kohji
Department Of Physiology 2 Tokai University School Of Medicine
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INUBUSHI TETSURO
Department of Biophysics, University, of Pennsylvania
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Inubushi Tetsuro
Department Of Biophysics University Of Pennsylvania
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Nakazawa Hiroe
Department Of Physiology 2 Tokai University School Of Medicine
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Ichimori Kohji
Department of Chemistry, Faculty of Science, Kyoto University
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