MCH(ICR)マウス分娩遅延のための適正プロジェステロン濃度の検討

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概要

• 論文の詳細を見る

• The effects of progesterone (P4) used in physiological studies and in delayed parturition in reproductive engineering were examined. A dose of 0.25, 0.5, 1, or 2 mg of P4 was repeatedly administered to Jcl:MCH(ICR) mice on days 17 and 18 of gestation, and plasma concentrations of P4 were investigated. The P4 concentrations in mothers and fetuses after administration of exogenous P4 were no differences between doses of 1 and 2 mg. Jcl:MCH(ICR) mothers administered a P4 dose of 1 mg did not give birth. Therefore, we consider 2 mg of P4 is an overdose and that it is evident that a dose of 1 mg P4 is sufficient to induce delayed parturition.

著者

• 橋本 晴夫

  Central Institute for Experimental Animals

• 江藤 智生

  Central Institute for Experimental Animals

• 遠藤 圭子

  Central Institute for Experimental Animals

• ITAI Gen

  Central Institute for Experimental Animals

• KAMISAKO Tsutomu

  Central Institute for Experimental Animals

• SUEMIZU Hiroshi

  Central Institute for Experimental Animals

• ITO Mamoru

  Central Institute for Experimental Animals

• Kamisako Tsutomu

  Central Inst. For Experimental Animals

• HASHIMOTO Haruo

  Central Institute for Experimental Animals

• Hashimoto Haruo

  Central Inst. For Experimental Animals

• ETO Tomoo

  Central Institute for Experimental Animals

• ENDO Keiko

  Central Institute for Experimental Animals

• Ito Mamoru

  Central Inst. For Experimental Animals Kawasaki Jpn

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