Reduced Adiponectin Level Is Associated With Severity of Coronary Artery Disease
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概要
- 論文の詳細を見る
Adipocyte-derived adiponectin has an antiatherosclerotic effect that acts independently of its antidiabetic effect. Plasma adiponectin levels are generally low in subjects with coronary artery disease. In this study, the relationship between the plasma adiponectin level and the severity of coronary artery disease, as assessed using the Gensini score, an index for the severity of coronary artery stenosis, was investigated. The subjects of the study were 104 patients (72 men and 32 women; BMI, 23.5 ± 3.3 kg/m2; age, 63.6 ± 10.1 years) admitted to Tokyo University Hospital for coronary angiography. Plasma adiponectin levels were inversely correlated with the insulin resistance index HOMA-IR (P = 0.0127). The plasma adiponectin level was significantly associated with the Gensini score (P = 0.0332). After adjustment for conventional risk factors for cardiovascular diseases, the plasma adiponectin level tended to be inversely correlated with the Gensini score (P = 0.087). The measurement of plasma adiponectin levels may be useful for predicting the severity of coronary artery stenosis.
- インターナショナル・ハート・ジャーナル刊行会の論文
著者
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NAGAI Ryozo
Department of Cardiovascular Medicine, University of Tokyo
-
Kadowaki Takashi
Department of Health Science, Shiga University of Medical Science
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Imai Yasushi
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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YAMAUCHI Toshimasa
Department of Metabolic Diseases, The University of Tokyo
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Hara Kazuo
Departments of Diabetes and Metabolism, Graduate School of Medicine, the University of Tokyo
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Manabe Ichiro
Department Of Cardiovascular Medicine The University Of Tokyo
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Yamauchi Toshimasa
福岡大学 心臓･血管内科学
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