Antitumor Effect of Bevacizumab in a Xenograft Model of Canine Hemangiopericytoma
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概要
- 論文の詳細を見る
Canine hemangiopericytoma (CHP) is characterized by frequent local recurrence and increased invasiveness. Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis in tumors. The aim of the present study was to investigate the effect of a single dose of bevacizumab on a xenograft model of CHP. VEGF protein was secreted from cultured CHP cells and interacted with bevacizumab. Bevacizumab treatment suppressed tumor growth by inhibiting tumor angiogenesis, whereas no significant differences were observed in the proliferation index and apoptosis rates of treated and untreated mice. Thus, bevacizumab had antitumor effects in a xenograft model of CHP.
著者
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Tajima Tsuyoshi
Department Of Clinical Radiology Graduate School Of Medical Sciences Kyushu University
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Ogihara Kikumi
Department Of Environmental Pathology Azabu University
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Takahashi Kimimasa
Department Of Veterinary Pathology Nippon Veterinarv Animal And Science University
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Kishikawa Seigo
Department Of Environmental Pathology Azabu University
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Yoshimura Hisashi
Department Of Biology Faculty Of Science Shizuoka University
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Michishita Masaki
Department Of Veterinary Pathology Nippon Veterinary Animal And Science University
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AZAKAMI Daigo
Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University
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Azakami Daigo
Department of Veterinary Nursing, Nippon Veterinary and Life Science University, Japan
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Arai Toshiro
Department of Veterinary Biochemistry, Nippon Veterinary and Life Science University, Japan
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ARAI Toshiro
Department of Biochemistry, Nippon Veterinary and Animal Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan
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Naya Yuko
Department of Pathology, School of Life and Environmental Science, Azabu University, Japan
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Tajima Tsuyoshi
Department of Veterinary Pharmacology, Nippon Veterinary and Life Science University, Japan
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Uto Tatsuya
Department of Veterinary Pathology, Nippon Veterinary and Life Science University, Japan
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Nakazawa Ryota
Department of Veterinary Pathology, Nippon Veterinary and Life Science University, Japan
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