Patient-Side Assay of Lipase Activity Correlating with Pancreatic Lipase Immunoreactivity in the Dog

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概要

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• Pancreatitis is a common exocrine pancreatic disease in dogs, and pancreatic lipase immunoreactivity (PLI) test is used for diagnosis. Enzyme catalytic assay is thought to have low specificity, but lipase activity assay with increased specificity has been developed in human clinical chemistry. We measured serum lipase activity of the 65 client-owned dogs using the newly developed FUJI DRI-CHEM slide, and compared with their PLI concentrations. These results showed a good correlation (r=0.91), and the normal and pancreatitis dogs estimated from PLI values were completely separated based on lipase activity. It was suggested that FUJI DRI-CHEM lipase activity would be helpful for diagnosis of pacreatitis in dogs, and especially, it achieves the patient-side assay which contributes to the immediate treatment.

著者

• Ishioka Katsumi

  Department Of Physiology Faculty Of Veterinary Medicine Hokkaido University

• HAYAKAWA Noriyuki

  Veterinary Medical Teaching Hospital, Nippon Veterinary and Life Science University

• NAKAMURA Kentaro

  Pharmaceutical & Healthcare Research Laboratories, Research & Development Management Headquarters, F

• TERASHIMA Kaoru

  Pharmaceutical & Healthcare Research Laboratories, Research & Development Management Headquarters, F

• ISHIOKA Katsumi

  Department of Veterinary Nursing, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University

• TERASHIMA Kaoru

  Pharmaceutical & Healthcare Research Laboratories, Research & Development Management Headquarters, FUJIFILM Corporation

• NAKAMURA Kentaro

  Pharmaceutical & Healthcare Research Laboratories, Research & Development Management Headquarters, FUJIFILM Corporation

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