Sedative Effect of Medetomidine and its Reversal by Atipamezole in House Musk Shrews (Suncus murinus)

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This study was undertaken to evaluate the sedative effect of medetomidine, an α2-adrenoceptor agonist, and the counteractive effect of atipamezole, an antagonist to medetomidine, in house musk shrews (Suncus murinus). Two hundred, 300, 400, or 600 μg/kg of medetomidine was intraperitoneal injected into 89 house musk shrews. A sedative effect was produced in one to two minutes after injection. The dose-dependent prolongation of the sedative duration and the dose-dependent appearance of a hypothermic effect were demonstrated. With 200 μg/kg of medetomidine, the sedative effect obtained was not adequate in some of the animals. With 300 μg/kg and above, a stable sedative state was induced in all the animals. The duration of sedation in the house musk shrews was much longer (p<0.01) in males than in females. This suggested the higher susceptibility of male house musk shrews to this drug. The sedative effect and hypothermia obtained with 400 μg/kg of medetomidine were completely counteracted by more than 2.0 mg/kg of atipamezole. With 0.5 and 1.0 mg/kg of atipamezole, only a partial antagonistic action was produced. Transient vomiting appeared in 4.5% of the house musk shrews at approximately one minute after injection of medetomidine. This side-effect had occurred before the sedative effect was obtained, and was not serious enough to be a problem. None of the 89 house musk shrews died in this experiment. The above results show that the combination of medetomidine and atipamezole is a highly effective and safe anesthetic treatment which permits easy handling of house musk shrews.
社団法人　日本実験動物学会の論文

Sedative Effect of Medetomidine and its Reversal by Atipamezole in House Musk Shrews (Suncus murinus)

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