Enhanced Type X Collagen Expression in the Extruded Nucleus Pulposus of the Chondrodystrophoid Dog
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概要
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The causes of early degeneration and calcification of the nucleus pulposus in the chondrodystrophoid dog are poorly understood, and the underlying molecular mechanism of this process has not yet been clearly defined. Type X collagen is one of the key molecules in endochondral bone growth and development, especially matrix calcification. The relationship between type X collagen and disc degeneration and calcification in chondrodystrophoid dogs has not yet been studied. We analyzed the expression of type X collagen in degeneration and calcification of the intervertebral disc in chondrodystrophoid dogs, using type X collagen immunohistochemistry. Control intervertebral discs were collected from five dogs (4 female, 1 male, average age 1.3 years, beagle breed). Degenerated intervertebral discs were surgically removed from 11 canine patients with intervertebral disc extrusion (1 female, 10 male, average age 5.1 years, dachshund breed) in Nippon Veterinary and Animal Science University. All extruded disc samples showed hypertrophic changes and clustering of cells, typical features observed in the degenerated nucleus pulposus. The relative expression of type X collagen in the degenerated nucleus pulposus (84.3 ± 11.0%) was significantly increased compared to the control nucleus pulposus (5.4 ± 5.4%). Our findings suggest that type X collagen might contribute to the development of degeneration or calcification in the nucleus pulposus of the chondrodystrophoid dog.
- 公益社団法人 日本獣医学会の論文
著者
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Shinomiya Kenichi
Department Of Frontier Surgical Therapeutics Division Of Advanced Therapeutical Sciences Graduate Sc
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Haro Hirotaka
Department Of Frontier Surgical Therapeutics Division Of Advanced Therapeutical Sciences Graduate Sc
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Hara Yasushi
Division Of Veterinary Surgery Nippon Veterinary And Animal Science University
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Tagawa Masahiro
Division Of Surgery Nippon Veterinary And Animal Science University
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TAGAWA Masahiro
Division of Veterinary Surgery, Nippon Veterinary and Animal Science University, School of Veterinary Medicine
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ITOH Hisanori
Division of Veterinary Surgery, Nippon Veterinary and Animal Science University, School of Veterinary Medicine
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ASOU Yoshinori
Department of Orthopaedic Surgery, Tokyo Medical and Dental University
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HARA Yasushi
Division of Veterinary Surgery, Nippon Veterinary and Animal Science University, School of Veterinary Medicine
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