Efficacy of Transsphenoidal Surgery on Endocrinological Status and Serum Chemistry Parameters in Dogs with Cushings Disease
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概要
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Postoperative changes in the endocrinological status and serum chemistry during the 4 years after transsphenoidal surgery (TSS) in 25 dogs with Cushings disease were investigated in a prospective study. In all 25 dogs, Cushings disease was diagnosed from resected pituitary tissues as a corticotroph adenoma in the anterior lobe of the pituitary. Prior to TSS, all 25 dogs showed hypercortisolemia. After TSS, ACTH-stimulation test showed continued low serum cortisol concentrations in 21 dogs (84%). In addition, serum thyroid stimulating hormone concentrations decreased sequentially, while serum T4 concentrations tended to increase from the postoperative hormone substitution therapy to avoid secondary hypothyroidism. In regard to serum chemistry, alkaline phosphatase (ALP), alanine aminotransferase (ALT), and total cholesterol are commonly increased in canine Cushings disease. In this study, ALP, ALT, and total cholesterol were also increased in 23 cases (92%), 19 cases (76%), and 20 cases (80%), respectively. However, postoperatively, those concentrations gradually decreased. The postoperative serum concentrations of ALP at 1 year, that of ALT at six months to 2 years, and that of total cholesterol during the 4 years decreased significantly compared to the concentrations before TSS. These results show that TSS is an effective treatment for canine Cushings disease and for the long-term improvement of hypercortisolemia. Moreover, TSS is effective in the improvement of hypercortisolism, such as increased concentrations of serum ALP, ALT, and total cholesterol.
著者
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TERAMOTO Akira
Departments of Neurosurgery, Nippon Medical School
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HARA Yasushi
Divisions of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science U
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TESHIMA Takahiro
Divisions of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science U
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TAODA Takahiro
Department of Small Animal Surgery 2, School of Veterinary Medicine, Kitasato University
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ISHINO Hirokazu
Divisions of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science U
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NEZU Yoshinori
Divisions of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science U
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HARADA Yasuji
Divisions of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science U
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YOGO Takuya
Divisions of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science U
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MASUDA Hiroyuki
Divisions of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science U
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TAGAWA Masahiro
Divisions of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science U
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Yogo Takuya
Division Of Veterinary Surgery Department Of Veterinary Science Faculty Of Veterinary Medicine Nippo
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Nezu Yoshinori
Division Of Veterinary Surgery Department Of Veterinary Science Faculty Of Veterinary Medicine Nippo
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Hara Yasushi
Division Of Veterinary Surgery Nippon Veterinary And Animal Science University
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Tagawa Masahiro
Division Of Surgery Nippon Veterinary And Animal Science University
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Teramoto Akira
Department Of Functional Polymer Science Shinshu University
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HARADA Yasuji
Divisions of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science University
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HARADA Yasuji
Division of Veterinary Surgery, Department of Veterinary Medicine, Nippon Veterinary and Life Science University
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MASUDA Hiroyuki
Divisions of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science University
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MASUDA Hiroyuki
Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University
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YOGO Takuya
Divisions of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science University
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TAGAWA Masahiro
Divisions of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science University
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TESHIMA Takahiro
Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University
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TESHIMA Takahiro
Divisions of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science University
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ISHINO Hirokazu
Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University
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NEZU Yoshinori
Divisions of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science University
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HARA Yasushi
Divisions of Veterinary Surgery, School of Veterinary Medicine, Nippon Veterinary and Life Science University
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