Helical Conformation Endows Poly-L-Lactic Acid Fibers with a Piezoelectric Charge under Tensile Stress
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概要
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Poly-<span style="font-variant: small-caps;">l</span>-lactic acid (PLLA) has been clinically used as a bioabsorbable material and attains a piezoelectric charge upon molecular orientation by the application of a shear force to the C-axis of the crystal line region. Previous studies showed that implanted drawn PLLA films or rods accelerate the ossification due to piezoelectric effect. In this study, we originally designed helically-twisted PLLA fiber to produce piezoelectricity in bioabsorbable suture upon tensile stress. The piezoelectricity of the helical PLLA fibers was evaluated using a lock-in amplifier system in vitro. The ossification induced by helical PLLA fibers was examined by implanting them in the rat patellar ligament supporting a physiological tensile load. We observed that 57° and 45° twisted PLLA fibers generated a higher piezoelectric potential than did 27° twisted fibers. The animal experiment showed that the formation of osseous tissue around helical PLLA fibers was more significant than around non-helical control fibers at 4 weeks after their implantation. These results suggest that helical PLLA fiber may be useful for the surgical suture or artificial ligament, which connects to the bone.
著者
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Ikada Yoshito
Department Of Cardiovascular Surgery Heart Institute Of Japan Tokyo Women's Medical University
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Kadono Kunihiko
Department Of Orthopaedic Surgery Nara Medical University
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HARADA Yasuji
Division of Veterinary Surgery, Nippon Veterinary and Life Science University, 1–7–1 Kyonan-cho, Musashino-shi, Tokyo 180–8602, Japan
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HARADA Yasuji
Division of Veterinary Surgery, Department of Veterinary Medicine, Nippon Veterinary and Life Science University
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TERAO Tomohiro
Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606–8501, Japan
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SUZUKI Masakazu
Research and Development Department, GUNZE LIMITED, 46 Natsumegaichi, Aono, Ayabe, Kyoto 623–8513, Japan
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TOMITA Naohide
Department of Mechanical Engineering, Graduate School of Engineering, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto 606–8501, Japan
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IKADA Yoshito
Department of Bioenvironmental Medicine, Nara Medical University, 840 Shijoh-cho, Kashihara-shi, Nara 634–8521, Japan
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TOMITA Naohide
Department of Mechanical Engineering and Science, Graduate School of Engineering, Kyoto University
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