Replication of Rat Coronaviruses in Intestinal Cell Line, RCN-9, Derived from F344 Rats
スポンサーリンク
概要
- 論文の詳細を見る
To examine the susceptibility of the epithelial cell line to rat coronavirus (RCV), we inoculated sialodacryoadenitis virus and Parker’s RCV into five cell lines; JTC-19, rat L2, LLC, RCN-9 and LBC cells originating in the lungs, intestines and mammary tumors of rodents. Both RCVs were replicated in LBC and RCN-9 cells, but not in the others. The infectivity titers of both RCVs grown in RCN-9 cells were significantly higher than those in LBC cells in every passage (2.5-3.9 log rate). Both RCVs replicated in LBC cells showed higher tropism to RCN-9 cells than to LBC cells, suggesting that RCN-9 cells are more suitable for the replication of RCVs than LBC cells. The RCN-9 cell line would be useful for the investigation of RCV infection in rodents.
- 社団法人 日本実験動物学会の論文
- 1996-10-01
著者
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佐藤 浩
長崎大学先導生命科学研究支援センター
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大澤 一貴
長崎大学先導生命科学研究支援センター
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佐藤 浩
長崎大学医学部附属動物実験施設
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TAKAKURA Akira
Central Institute for Experimental Animals
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ITOH Toshio
Central Institute for Experimental Animals
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Watanabe Yuka
Department Of Genetics Central Institute For Experimental Animals
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大沢 一貴
長崎大学先導生命科学研究支援センター・比較動物医学分野
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Ohsawa Kazutaka
Biomedical Research Center For Frontier Life Sciences Nagasaki University Graduate School Of Biomedi
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Ohsawa Kazutaka
Laboratory Animal Center For Biomedical Research Nagasaki University School Of Medicine
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SATO Hiroshi
Laboratory Animal Center for Biomedical Research, Nagasaki University School of Medicine
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WATANABE Yoji
Laboratory Animal Center for Biomedical Research
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Watanabe Yoji
Laboratory Animal Center For Biomedical Research Nagasaki University School Of Medicine
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Ohsawa Kazutaka
Div. Of Comparative Medicine Center For Frontier Life Sciences Nagasaki Univ.
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Sato H
Osaka Univ. Toyonaka
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