Induced Transgenerational Genetic Effects in Rodents and Humans
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概要
- 論文の詳細を見る
Delayed appearance of induced mutations has been observed in Drosophila, plants, rodents and recently in humans. The significance of this phenomenon is now recognized especially after the pioneering work of Nomura demonstrating transgenerational tumour induction in mice following treatment with urethane or ionizing radiation. A brief review of the literature on transgenerational genetic effects, namely, chromosomal aberrations and mutations, in rodents and humans is presented here.
- 日本放射線影響学会の論文
著者
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Sun Ye-qing
Department Of Life Science And Engineering Harbin Institute Of Technology
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FURUSAWA Yoshiya
National Institute of Radiological Sciences
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Xin Ping
Department Of Life Science And Engineering Harbin Institute Of Technology
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Xia Hong-mei
Department Of Life Science And Engineering Harbin Institute Of Technology
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Guan Shuang-hong
Department Of Life Science And Engineering Harbin Institute Of Technology
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Yang Qian
Department Of Infectious Diseases The First Hospital Of Xi'an Jiaotong University
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Natarajan A.
Dept. Toxicogenetics Leiden University Medical Centre:dept. Agrobiologia & Agrochimica Universit
関連論文
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- Reversed dose-rate effect of high LET radiation in mutation induction
- Induction of Micronuclei in Germinating Onion Seed Root Tip Cells Irradiated with High Energy Heavy Ions
- Heavy ion CT system based on measurement of residual range distribution
- Heavy Ion CT Reconstructed from Residual Range Distribution Measured by Range Shifter and Fluoroscopy System
- Sensitometric Properties in Heavy Ion Radiography
- Residual range distribution measured by heavy ion radiography
- Study of the ^7Be (p,γ)^8B Reaction with the Coulomb Dissociation Method
- PE-328 Heavy Ion Radiation Upregulates Connexin43 and Ameliorates the Substrates for VT/VF in Rabbit Hearts after Myocardial Infarction(Arrhythmia, basic-4 (A) PE55,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Ci
- Electrical Inhomogeneity and Instability of Rabbit Ventricles after Non-Transmural Myocardial Infarction : A High-Resolution Optical Mapping Analysis(Arrhythmia, Basic 2 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Heavy Ion Radiation Ameliorates the Substrates for VT/VF in Rabbit Hearts after Myocardial Infarction(Arrhythmia, Basic 1 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Proton dosimetry intercomparison based on the ICRU protocol
- RBE and Dose Distribution of Heavy Ion Beams.
- LET spectra of HZE particle beams in a tissue-equivalent material
- Measurements of HIMAC Therapy Beam Qualities
- Protective Effects of Melatonin Against Low- and High-LET Irradiation
- Repair of Skin Damage During Fractionated Irradiation with Gamma Rays and Low-LET Carbon Ions
- Biological Gain of Carbon-ion Radiotherapy for the Early Response of Tumor Growth Delay and against Early Response of Skin Reaction in Mice
- 269 Significance of beta term in carbon-ion radiotherapy(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 265 Relationship between RBE values of Carbon Ion and Tumor Growth Rate(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 258 Different Responses of Malignant Melanomas and Squamous Cell Carcinomas to X-rays and Heavy-ion Beams-II(Bases of radiotherapy, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Radioprotective Effects of Beer on Radiation-Induced Acute Toxicity in Mice
- Dependence of Gut-crypt Sensitivity on the Time Interval between Two Fractions of Carbon Ion Radiation
- Tumor Growth Rate and RBE values of high LET Carbon Ions
- Dependence of Carbon-Ion RBE on Dose Size -Difference between Skin and Tumors
- Different Responses of Malignant Melanomas and Squamous Cell Carcinomas to X-rays and Heavy-ion Beams
- Relative Biological Effectiveness of 290 MeV/u Carbon Ions for the Growth Delay of a Radioresistant Murine Fibrosarcoma
- Synthesis and Evaluation of 4-Bromo-1-(3-[^F]fluoropropyl)-2-nitroimidazole with a Low Energy LUMO Orbital Designed as Brain Hypoxia-Targeting Imaging Agent
- RBE of Carbon Ions for Tumor Growth Delay
- Fractionated irradiation with carbon ions induced resistance in mouse gut crypt cells
- Relative Biological Effectiveness of the 235 MeV Proton Beams at the National Cancer Center Hospital East
- Effects of sequentially mixed LET on tumor growth delay
- Fractionated irradiation with carbon ions to gut intestinal crypt cells
- Analysis of Mutations in the Human HPRT Gene induced by High LET Heavy-ion Irradiation
- Analysis of Mutations in the Human HPRT Gene Induced by Heavy-ion Irradiation II
- Dose response relations in acute cell death of pancreatic islet after whole body irradiatbn of gotlen harnster with gamma, proton and carton beams.
- Exploration of 'Over Kill Effect' of High-LET Ar-and Fe-ions by Evaluating the Fraction of Non-hit Cell and Interphase Death
- Analysis of Cytogenetic Damage in Rice Seeds Induced by Energetic Heavy Ions On-ground and After Spaceflight
- Dosimetry for heavy-ion radiation fields of argon, iron and kripton beams.
- LET, cell cycle dependence for mutation induction and spectrum in HPRT locus
- Cell Cycle and LET Dependence for Radiation-induced Mutation : A Possible Mechanism for Reversed Dose-rate Effect
- Depth Encoding of Point-of-Interaction in Thick Scintillation Cameras
- Effects of fractionated irradiation with carbon ions on the NFSa fibrosarcoma in mice
- Effectiveness of Monoenergetic and Spread-Out Bragg Peak Carbon-Ions for Inactivation of Various Normal and Tumour Human Cell Lines
- Biological Intercomparison Using Gut Crypt Survivals for Proton and Carbon-Ion Beams
- Relationship between Aberration Yield and Mitotic Delay in Human Lymphocytes Exposed to 200 MeV/u Fe-ions or X-rays
- Heavy ion radiography
- The Irradiation of an Accelerated Heavy ion Beam : Application to the Anti-Arrhythmic Therapy without Massive Myocardial Damage
- Correlation with cell death and chromatin damage by accelerated carbon ion beams
- Verification of ^C-290 MeV/u Tlieraputic Beams for HIMAC Clinical Trial using Mammalian cells
- The uniformity of the biological dose accelerated carbon ion beams with the spread out Bragg peak.
- Heavy ion radiation up-regulates Cx43 and ameliorates arrhythmogenic substrates in hearts after myocardial infarction
- Development of multichanel Ion Chamber for measurement of 3 dimensional dose Distributions of Heavy-Ion Therapeutic Beam in patients
- Reconstruction of Dose Calculation on CT-Image from Dose Distribution in Water Phantom
- Numerical Study on Range Measurement System with Positron Camera
- The Spot Scanning Irradiation with ^C Beams
- A Proton Dose Calculation Code for Treatment Planning Based on the Pencil Beam Algorithm
- Analysis of the Penumbra for Uniform Irradiation Fields Delivered by a Wobbler method
- Comparative study of He, C, Ne and Ar beams for heavy-ion radiation therapy : Motivation and preliminary result of the comparison -
- Bone marrow death is not always more sentitive than intestinal death in Mongolian gerbils ? II Radiosensitivity of bone marrow stem cells.
- Time Course of Reoxygenation in Experimental Murine Tumors after Carbon-beam and X-ray Irradiation
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- Number of Fe Ion Traversals Through a Cell Nucleus for Mammalian Cell Inactivation Near the Bragg Peak
- 210 Mutation Spectrum of Bacillus subtilis Spore Irradiated With Heavy Ion Near the Bragg Peak(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- 200 Each Ion Traversal Induces a DSB Cluster in Cell Nucleus(Physics, chemistry and DNA damage, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Induction of Chromatin Damage and Distribution of Isochromatid Breaks in Human Fibroblast Cells Exposed to Heavy Ions
- Distribution of Heavy Ion-Induced G2 Chromatin Damage and Repair in Human Fibroblast Cells
- Analysis of Unrejoined Chromosomal Breakage in Human Fibroblast Cells Exposed to Low- and High-LET Radiation
- Heavy-ion Induced Initial G2-chromosome aberrations and Repair Kinetics of Normal Human Fibroblasts
- 8^ International Workshop on Microbeam Probes of Cellular Radiation Response
- Repair Kinetics of DNA-DSB Induced by X-rays or Carbon Ions under Oxic and Hypoxic Conditions
- Cell cycle and LET dependence for 6-thioguanine-resistant mutation induced by heavy ion beam in mouse L5178Y cells
- Heavy-ion Induced Chromatid Break and Repair Kinetics in Normal Human Fibroblasts
- Effects of Neon Beam on Hematopoietic Stem Cells in Mice
- Effects of Carbon Beani on Survival and Hematopoietic Stem Cells in Mice
- Effects of NIPS HIMAC Carbon Beam on Hematopoietic System in Mice.
- nteraction Between Ion Beam and X-ray on Radiobiological Effects II
- Influence of the Shielding on the Induction of Chromosomal Aberrations in Human Lymphocytes Exposed to High-energy Iron Ions
- Early skin reactions after fractionated irradiation of 290MeV/u Carbon- 12
- Enhancement of X-ray-induced apoptosis by lonidamine
- Reoxygenation of Experimental Murine Tumors after Carbon Beam Irradiation : Evaluation by Colony Assay.
- Induced Transgenerational Genetic Effects in Rodents and Humans